Kinetic Analysis of LY320236: Competitive Inhibitor of Type I and Non-Competitive Inhibitor of Type II Human Steroid 5α-Reductase

    January 2000 in “ The Journal of Steroid Biochemistry and Molecular Biology ”
    Ann M. McNulty, James E. Audia, Kerry G. Bemis … Blake Lee Neubauer
    Studysummary This study found that LY320236 is a competitive inhibitor of type I and a non-competitive inhibitor of type II steroid 5alpha-reductase, indicating its potential as a dual inhibitor with differing modes of activity.
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    Research cited in this study 4

    1. FCE 28260, A New 5α-Reductase Inhibitor: In Vitro and In Vivo Effects The Journal of Steroid Biochemistry and Molecular Biology · 1996
    2. LY191704: A Selective, Nonsteroidal Inhibitor of Human Steroid 5 Alpha-Reductase Type 1 Proceedings of the National Academy of Sciences of the United States of America · 1993
    3. Nonsteroidal Inhibitors of Human Type I Steroid 5α-Reductase Journal of Medicinal Chemistry · 1993
    4. Species Differences in Prostatic Steroid 5α-Reductases of Rat, Dog, and Human Endocrinology · 1985

    Related research 1

    1. Kinetic Analysis of LY320236: Competitive Inhibitor of Type I and Non-Competitive Inhibitor of Type II Human Steroid 5α-Reductase The Journal of Steroid Biochemistry and Molecular Biology · 2000