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Oxidative Activity of the Type 2 Isozyme of 17β-Hydroxysteroid Dehydrogenase Predominates in Human Sebaceous Glands

research Oxidative Activity of the Type 2 Isozyme of 17β-Hydroxysteroid Dehydrogenase (17β-HSD) Predominates in Human Sebaceous Glands

45 citations , September 1998 in “Journal of Investigative Dermatology”

This study found that sebaceous glands predominantly exhibit oxidative activity of the type 2 17β-hydroxysteroid dehydrogenase isozyme, which is not inhibited by 13-cis retinoic acid.

research Determination of rat 5α-reductase type 1 isozyme activity and its inhibition by novel steroidal oxazolines

4 citations , August 2010 in “Acta Biologica Hungarica”

This study found that novel compounds moderately inhibited 5α-reductase type 1 activity compared to finasteride, offering valuable data on structure-activity relationships.

research LY191704: a selective, nonsteroidal inhibitor of human steroid 5 alpha-reductase type 1.

53 citations , June 1993 in “Proceedings of the National Academy of Sciences of the United States of America”

This study identified LY191704 as a specific noncompetitive inhibitor of human 5 alpha-reductase type 1, which may be useful in treating endocrine disorders related to DHT overproduction.

research Immunolocalization of 5α-Reductase Isozymes in Acne Lesions and Normal Skin

45 citations , September 2000 in “Archives of dermatology”

This study found that 5alpha-reductase type 1 localizes specifically to sebaceous glands in both normal and acne follicles, suggesting its role in sebum regulation.

research The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases

218 citations , December 2011 in “Advances in Urology”

This review discusses the biochemical properties and clinical significance of 5 alpha-reductase isozymes and reports no new clinical results.

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community Green tea/ soy Isoflavones supplements for MPB

4 upvotes 5 years ago

Green tea extract and soy isoflavones may help with hair loss by inhibiting DHT and providing additional health benefits. Combining these with finasteride and possibly using nizoral shampoo could enhance effectiveness in managing hair loss.

community Is this finasteride brand legit?

in Finasteride/Dutasteride 15 upvotes 7 months ago

The conversation discusses the use of dutasteride and minoxidil for hair loss treatment, with concerns about potential side effects and the effectiveness of dutasteride compared to finasteride. The user is advised to monitor for side effects and consult with a doctor, while also considering the differences between the medications.

community Did anybody use beta sisterol for hair loss? I saw in many articles in the internet that said that beta sisterol blocks dht by inhibiting 5a reductase type 2 enzyme and some reviews of people who said that it worked better than saw palmetto in terms of stoping hair loss and helping prostate.

in Research/Science 9 upvotes 3 years ago

Beta-sitosterol may inhibit 5-alpha reductase type 2 enzyme, potentially reducing DHT levels and promoting hair growth, similar to finasteride but possibly with fewer side effects. Its effectiveness and side effects compared to other treatments like saw palmetto and finasteride remain uncertain due to limited research.

community Interesting new publication suggesting that MPB should be assessed as a early warning sign for type-2 diabetes.

15 upvotes 8 years ago

Male pattern baldness (MPB) may be an early warning sign for type 2 diabetes due to its association with insulin resistance. Treatments discussed include testosterone therapy and finasteride, which affects hormone levels related to hair loss and insulin sensitivity.

community 5 alpha reductase type 1 is in brain tissue producing the main endogenous gabaergic allopregnanolone, not 2. How can finasteride as a 5ar2 lower that?

27 upvotes 1 year ago

Finasteride and dutasteride are discussed for hair loss, with concerns about their effects on neurosteroids and potential side effects like depression. Alternatives like topical estrogen and lifestyle changes are considered, with varying opinions on mental health and hair regrowth.

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learn Hair Transplant

What are the different hair transplant techniques? The main hair transplant techniques are FUE, DHI, and FUT, each with unique benefits.
Who is a good candidate for a hair transplant? Good candidates for hair transplants have sufficient donor hair and stable hair loss patterns.

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