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The enzyme 17β-HSD type 2 mainly performs oxidation in human sebaceous glands, which may help protect against acne.

New steroidal compounds moderately block an enzyme related to testosterone conversion, less effectively than finasteride.

The compound 4c effectively inhibits the enzyme linked to hair loss.

LY191704 is a compound that effectively blocks a specific enzyme involved in hormone conversion and could help treat enlarged prostate and hair loss.

The study found that the enzyme linked to acne is present in the same areas of both acne-affected and normal skin.

The study found that two enzymes linked to hair loss are located in different parts of the scalp, supporting a common treatment's effectiveness.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

The enzyme type 1 5α-reductase is more active in the hair follicle's lower part than in the skin's outer layer.

Selective non-steroidal inhibitors of 5α-reductase type 1 can help treat DHT-related disorders.

New chemicals were made that can block an enzyme linked to hair loss, prostate growth, and acne.

Saw palmetto extract can block the enzyme that converts testosterone in pig prostate cells.

New treatments for prostate cancer and BPH show promise, including novel compounds that target hormone synthesis and response.

Blocking the enzyme 5α-reductase can shrink the prostate and help treat enlarged prostate issues.

FCE 28260 is a stronger and longer-lasting inhibitor of 5α-reductase than finasteride, which may make it a better treatment for certain medical conditions.

No consistent link between genotype and phenotype in 5-α-Reductase type 2 deficiency.

Three siblings with a rare genetic condition had abnormal sexual development and chose different gender identities, needing surgery and therapy.

Finasteride, when given in high oral doses to pregnant monkeys, caused genital abnormalities in male fetuses, but not in female fetuses or those exposed to intravenous finasteride.

New chemical compounds were made that effectively block an enzyme linked to prostate growth.

Androgen treatment with dihydrotestosterone may help maintain height in patients with 5-α-reductase type 2 deficiency, especially before puberty.

Finasteride effectively blocks rat enzymes, but with varying methods and strength.

Finasteride inhibits enzyme activity in rhesus macaques, suggesting they're useful for evaluating similar drugs.

Sebocytes play a key role in controlling androgen levels in human skin.

Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.

Blocking a specific enzyme might help treat obesity and diabetes, but more research is needed to ensure it's safe.

Scientists made new substances that can block an enzyme linked to prostate issues and hair loss, with potential for creating a new treatment.

Dicentrine reduced heart disease risk factors in rats, T-588 protected mice brains without side effects, Provir blocked herpes virus and lessened mouse symptoms, and LY191704 could treat hair loss and prostate issues.

Human sebaceous glands contain enzymes that affect androgen production and may influence sebum production and acne.

Researchers developed a model to predict how well certain compounds can block an enzyme related to hair loss and prostate issues, suggesting a 50 mg dose of finasteride might be effective based on lab and body data.

11α-Hydroxyprogesterone is changed into different substances by certain enzymes and may play a role in prostate cancer.

Long-term use of finasteride and dutasteride can cause serious health issues like diabetes and liver problems.