Cyclohex-1-Ene Carboxylic Acids: Synthesis and Biological Evaluation of Novel Inhibitors of Human 5α Reductase

March 2003 in “ Archiv Der Pharmazie ”

Eckhard Baston, Ola I. A. Salem, Rolf W. Hartmann

5α reductase androgenic alopecia 4-(2-phenylethyl)cyclohex-1-ene carboxylic acids prostatic isozyme 2 benign prostatic hyperplasia 5-alpha reductase hair loss BPH

TLDR Scientists made new substances that can block an enzyme linked to prostate issues and hair loss, with potential for creating a new treatment.

In 2003, researchers synthesized and evaluated novel inhibitors of human 5α reductase, an enzyme linked to conditions like benign prostatic hyperplasia and androgenic alopecia (hair loss). The study focused on compounds known as 4-(2-phenylethyl)cyclohex-1-ene carboxylic acids 1-5. These compounds were found to be effective inhibitors of the prostatic isozyme 2, with compound 1 being the most potent (IC50 = 760 nM). However, they only slightly inhibited isozyme 1. The researchers concluded that these compounds could be further optimized for the development of a new drug for the treatment of benign prostatic hyperplasia and potentially hair loss conditions.

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