Activity of Type 1 5α-Reductase Is Greater in the Follicular Infrainfundibulum Compared with the Epidermis
February 1997
in “
British Journal of Dermatology
”
type 1 5α-reductase type 2 5α-reductase follicular infrainfundibulum epidermis pilosebaceous unit androgens follicular keratinization acne vulgaris hirsutism male-pattern hair loss sex steroid hormone metabolism type 1 5-alpha-reductase type 2 5-alpha-reductase hair follicle skin oil gland male hormones hair growth acne excessive hair growth androgenic alopecia hormone processing
Studysummary This study found that 5α–reductase activity is higher in infrainfundibular keratinocytes compared to interfollicular epidermal keratinocytes, suggesting a potential role in acne-related follicular changes.
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