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    Research 10 of 1000+

    1. Effect of MK-386, a novel inhibitor of type 1 5 alpha-reductase, alone and in combination with finasteride, on serum dihydrotestosterone concentrations in men. The Journal of Clinical Endocrinology and Metabolism · 1996 · 6 citations
    2. LY191704: a selective, nonsteroidal inhibitor of human steroid 5 alpha-reductase type 1. Proceedings of the National Academy of Sciences of the United States of America · 1993 · 53 citations
    3. Sexual dimorphism of growth plate prehypertrophic and hypertrophic chondrocytes in response to testosterone requires metabolism to dihydrotestosterone (DHT) by steroid 5‐alpha reductase type 1 Journal of Cellular Biochemistry · 2005 · 27 citations
    4. The 5alpha-reductase type 1, but not type 2, gene is expressed in anagen hairs plucked from the vertex area of the scalp of hirsute women and normal individuals Brazilian Journal of Medical and Biological Research · 2003 · 17 citations
    5. Predominant expression of 5 alpha-reductase type 1 in pubic skin from normal subjects and hirsute patients. 1996 · 11 citations
    6. Effect of MK-386, a novel inhibitor of type 1 5 alpha-reductase, alone and in combination with finasteride, on serum dihydrotestosterone concentrations in men The Journal of Clinical Endocrinology and Metabolism · 1996 · 7 citations
    7. Activity of type 1 5α-reductase is greater in the follicular infrainfundibulum compared with the epidermis British Journal of Dermatology · 1997 · 12 citations
    8. Synthesis and in Vitro Evaluation of 4-Substituted N-(1,1-Dimethylethyl)-3-oxo-4-androstene-17.beta.-carboxamides as 5.alpha.-Reductase Inhibitors and Antiandrogens Journal of Medicinal Chemistry · 1995 · 12 citations
    9. Natural Product-Inspired Bis(trifluoromethyl) Phenyl Hydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitors of Human Steroid 5α-Reductase Type-1: Synthesis, <i>In Vitro</i>, and <i>In Silico</i> Studies ACS Omega · 2025
    10. Selective non-steroidal inhibitors of 5α-reductase type 1 2004 · 49 citations
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    Community 10 of 84

    1. 5 alpha reductase type 1 is in brain tissue producing the main endogenous gabaergic allopregnanolone, not 2. How can finasteride as a 5ar2 lower that? Reddit · 3 Oct 2024
    2. How come Dut doesn’t cause more brain problems than fin if it inhibits Type 1 5AR? Reddit · 26 Jun 2024
    3. 5ar Type I in the frontal hair follicles - Dutasteride Reddit · 30 Apr 2024
    4. Was scared to try fin and jumped straight to 2.5mg Dut? Reddit · 12 Sept 2026
    5. Thoughts on this Article: Post-Finasteride and Neurological Effects Reddit · 16 Mar 2024
    6. The truth about Dutasteride (w/ sources) Reddit · 24 Jan 2023
    7. Whats up with all the dutasteride destroying hair posts Reddit · 12 May 2023
    8. DHT and 5AR respect post, it's importance within the brain Reddit · 3 Mar 2024
    9. My story (22m, fin, min, niz, RU, dut –> part frontal hair system) Reddit · 6 May 2023
    10. Peptides that Stop Hair Loss? | In-depth Literature Review Video Reddit · 6 Jul 2024
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    Learn 3 of 6

    1. Finasteride Popular 5-alpha reductase inhibitor that lowers DHT, taken as a pill or used topically
    2. Dutasteride 5-alpha reductase inhibitor that blocks both enzyme types, a stronger DHT blocker than finasteride
    3. Neem Oil Oil from the neem tree, used in traditional remedies
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