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research Spatiotemporal Expression, Distribution, and Processing of POMC and POMC-derived Peptides in Murine Skin

49 citations , July 2000 in “Journal of Histochemistry & Cytochemistry”

This study found cell-specific variations in POMC mRNA and peptide expression in murine skin, suggesting that PC1 and PC2 convertases contribute to differential POMC processing.

Apocrine Sweat Gland Obstruction by Antiperspirants Allowing Transdermal Absorption of Cutaneous Generated Hormones and Pheromones as a Link to the Observed Incidence Rates of Breast and Prostate Cancer in the 20th Century

research Apocrine sweat gland obstruction by antiperspirants allowing transdermal absorption of cutaneous generated hormones and pheromones as a link to the observed incidence rates of breast and prostate cancer in the 20th century

18 citations , March 2009 in “Medical Hypotheses”

This review discusses the potential link between long-term transdermal exposure to sex hormones from antiperspirants and increased breast and prostate cancer rates, calling for further research to confirm this theory.

research In That Issue: Proceedings From the Third Intercontinental Meeting of Hair Research Societies

May 2003 in “Journal of Investigative Dermatology”

This article reviews the progress in hair biology research, including advancements in understanding androgen action, hair follicle stem cells, and autoimmune mechanisms in alopecia, and reports no new clinical results.

research Activity of type 1 5α-reductase is greater in the follicular infrainfundibulum compared with the epidermis

12 citations , February 1997 in “British Journal of Dermatology”

This study found that 5α–reductase activity is higher in infrainfundibular keratinocytes compared to interfollicular epidermal keratinocytes, suggesting a potential role in acne-related follicular changes.

research Cholesterol homeostasis: Links to hair follicle biology and hair disorders

25 citations , July 2019 in “Experimental Dermatology”

This review discusses the role of cholesterol homeostasis in hair follicle biology and its potential connections to various hair disorders, but it reports no new findings.

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community Dutasteride at 21 years old. Is it safe?

in Finasteride/Dutasteride 12 upvotes 2 years ago

A 21-year-old individual questioning the safety and potential side effects of using Dutasteride for hair loss, after Finasteride and RU58841 had limited effect. The responses vary, with some users suggesting it's safe and others advising to check hormone levels before proceeding.

community What is your hormone levels pre vs post finasteride?

1 upvotes 3 years ago

community How to reduce cortisol (stress hormone) naturally?

37 upvotes 4 years ago

The conversation discusses natural ways to reduce cortisol, such as avoiding caffeine, getting proper sleep, syncing with the sun, walking in nature, breathing exercises, increasing calories, and not doing keto. Magnesium supplements are recommended for stress reduction.

community Is it me or are people losing their hair very young now?

in Finasteride/Dutasteride 143 upvotes 6 years ago

People notice more young individuals experiencing hair loss and discuss possible reasons, such as diet, hormones, and stress. Some treatments mentioned include finasteride, dutasteride, and minoxidil.

community On Dutasteride 0.5mg ED for almost 2 years. Increasingly shedding hair for more than 5 months.

in Finasteride/Dutasteride 7 upvotes 1 year ago

The user experienced increased hair shedding after switching from finasteride to dutasteride, despite lifestyle improvements and additional treatments like oral minoxidil and PRP. They are concerned about persistent shedding, changes in hormone levels, and potential chronic telogen effluvium, and are considering a scalp biopsy for further investigation.

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Learn

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learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Centella

Sensitive to hormones? A centella scalp mask may help ease hidden inflamm Centella asiatica has anti-inflammatory and wound-healing effects in animal and cell studies, but no published research has tested a centella scalp mask on the human scalp, in hormonal contexts or otherwise, and no community reports were found of one being used this way.

learn Estradiol

Why is Estradiol used to treat hair loss in women and transgender people undergoing hormone therapy? Estradiol helps treat hair loss by balancing hormones and supporting hair follicle health.
Is applying Estradiol directly to the scalp effective for hormone-related hair thinning? Applying Estradiol directly to the scalp may help with hormone-related hair thinning.

learn procapil

Want to stop hormonal hair loss without touching your hormone levels? Procapil could block the enzyme doing the damage. Procapil's supplier describes it as inhibiting 5-alpha reductase at the scalp without changing hormone levels, but the published support is cell and animal work plus one small human study of a caffeine-plus-Procapil formula. It is a cosmetic ingredient, not an approved hair-loss treatment, and no trial has compared it with finasteride or minoxidil.

learn Clascoterone

Can I use clascoterone if I'm undergoing gender-affirming hormone therapy? No published clinical trial has tested clascoterone in people on gender-affirming hormone therapy, so its safety in that group is unknown. The FDA label reports low systemic exposure and no described effect on blood testosterone, but it also records HPA-axis suppression and raised potassium in a small minority of subjects.

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