Androgen Receptor-Mediated Inhibition of Cutaneous Wound Healing

The study reported that castration of male mice significantly accelerated cutaneous wound healing, reduced inflammation, and increased hair growth. This effect was attributed to testosterone reduction, which directly influenced wound cell populations rather than hair follicle cell proliferation. The findings suggested that endogenous testosterone inhibited wound healing in males by upregulating proinflammatory cytokine expression in macrophages. Blocking androgen action through receptor antagonism also accelerated healing, indicating a potential therapeutic target for improving wound healing in elderly males.