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research Peroxisome proliferator-activated receptors (PPARs) and PPAR agonists: the ‘future’ in dermatology therapeutics?

60 citations , May 2015 in “Archives of dermatological research”

This review discusses the role of peroxisome proliferator-activated receptors and their agonists in dermatology but reports no new clinical results.

Non-Clinical Safety Evaluation and Risk Assessment of Aleglitazar, a Dual PPAR α/γ Agonist, and Its Major Human Metabolite

research Non-clinical safety evaluation and risk assessment to human of aleglitazar, a dual PPAR α/γ agonist, and its major human metabolite

3 citations , March 2017 in “Regulatory toxicology and pharmacology”

In this study, aleglitazar and its metabolite M6 were evaluated for safety in non-clinical settings, revealing organ-targeting effects common to PPAR agonists but no significant tumor increase in rat carcinogenicity studies, supporting progression to Phase 3 clinical trials.

research Keratin 79 is a PPARA target that is highly expressed by liver damage

1 citations , January 2023 in “Biochemical and biophysical research communications”

This study found that hepatic KRT79 expression is regulated by PPARA and is significantly associated with liver stress, suggesting it may serve as a diagnostic marker for liver diseases.

research Severe Hair Loss of the Scalp due to a Hair Dye Containing Para phenylenediamine

20 citations , June 2011 in “ISRN Dermatology (Print)”

This case report describes a woman experiencing severe hair loss due to allergic contact dermatitis from a hair dye containing PPD.

research Influence of age and of testosterone on the response of male rats to parachlorophenylalanine

18 citations , September 1972 in “British Journal of Pharmacology”

In this study on male rats, parachlorophenylalanine treatment induced hypersexual behavior and hair loss linked to increased social interaction but had no effect on brain serotonin when testosterone was used instead.

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community Another theory for hair loss: Parasites in gut.

in Research/Science 9 months ago

Parasites in the gut may contribute to hair loss by depleting essential nutrients and disrupting hormone balance. An imbalance of hormones, not just DHT, could be a factor in androgenic alopecia.

community There's parabens in my Minoxidil, how bad is that?

2 upvotes 7 years ago

Parabens in Minoxidil are a concern for some users due to potential health risks. The conversation discusses the presence of methylparaben and propylparaben in a specific Minoxidil brand, Ylox.

community Mudei a Finasterida 1mg para Dutasterida 0,5mg

2 upvotes 2 weeks ago

The conversation discusses switching from finasteride 1mg to dutasteride 0.5mg due to thinning hair at the crown despite using finasteride and oral minoxidil. Another user mentions starting a combination pill with dutasteride, having previously used finasteride, minoxidil, and biotin.

community DHT Oily Scalp Dangers: Theory of an Oily Scalp and PPAR-GAMMA Dysregulation

in Research/Science 32 upvotes 1 year ago

Excessive scalp sebum, worsened by DHT, can lead to inflammation and hair loss, with clascoterone mentioned as a treatment. Diet changes seem ineffective for scalp sebum, and treatments like minoxidil and finasteride are suggested.

community Dutasteride worked at 3x/week, then paradoxically got worse after upping to 5x/week — DHT went UP, not down

31 upvotes 2 weeks ago

Increasing dutasteride from 3x to 5x a week led to worse hair loss and higher DHT levels, prompting a return to the original dosing. The user also uses topical minoxidil and is addressing a folic acid deficiency.

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Learn

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learn Hair Transplant

How should I prepare for a hair transplant? Clinics commonly ask patients to stop alcohol and smoking for days to weeks before a transplant, and to review blood-thinning medicines and supplements with their surgeon. Never stop a prescribed blood thinner on your own: only the doctor who prescribed it should change it.
Are hair transplants only for men? Hair transplants are suitable for both men and women.
Am I too young or too old for a hair transplant? You can be any age for a hair transplant, but stability of hair loss is crucial.

learn Scalp Micropigmentation

Who is a good candidate for scalp micropigmentation? Good candidates for scalp micropigmentation include anyone experiencing hair loss or thinning.
Can women get scalp micropigmentation? Yes, women can get scalp micropigmentation for hair loss or thinning.

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