Shedding Light on the Effects of Calorie Restriction and Its Mimetics on Skin Biology

    May 2020 in “ Nutrients ”
    Yeon Ja Choi
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    TLDR Eating fewer calories may slow skin aging and improve skin health through various biological changes.
    The document from May 2020 discussed the effects of calorie restriction and its mimetics on skin biology. It revealed that calorie restriction can promote structural and metabolic changes in the skin, potentially slowing the aging process. The role of sirtuins, specifically SIRT1, in regulating inflammation, cell migration, and wound healing in the skin was highlighted. The compound resveratrol, known to activate SIRT1, was discussed for its potential in skin care applications, including antioxidant properties, skin lightening efficacy, and potential in melanoma chemoprevention. The document also mentioned the use of nanocarriers for targeted topical skin delivery of resveratrol. The role of metformin in promoting lifespan and healthspan in various organisms by altering microbial folate and methionine metabolism was discussed, as well as its potential in alleviating endotoxemia-induced acute lung injury and inducing a dietary restriction-like state. The role of mTOR in skin aging and psoriasis, and the potential of rapamycin, an mTOR inhibitor, in reducing markers of senescence and aging in human skin were also discussed. Lastly, the role of peroxisome proliferator-activated receptors (PPARs) in skin biology and pathology, and their potential modulation by calorie restriction were discussed.
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