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Glossary Skin Permeability

ability of substances to pass through skin layers

Skin permeability refers to the ability of substances to pass through the skin barrier. This is important for the delivery of medications through topical treatments and for understanding how chemicals in the environment can affect the body. Factors like the condition of the skin, the size and solubility of the substance, and the presence of enhancers or barriers can influence how easily substances penetrate the skin.

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Research

5 / 1000+ results

research Severe Skin Permeability Barrier Dysfunction in Knockout Mice Deficient in a Fatty Acid ω-Hydroxylase Crucial to Acylceramide Production

40 citations , July 2019 in “Journal of Investigative Dermatology”

In this study, knockout mice lacking the Cyp4f39 gene showed severe skin barrier dysfunction and high early mortality, suggesting its critical role in skin barrier formation and insights into ichthyosis pathogenesis.

research Does dry skin indicate defective epidermal permeability barrier?

October 2022 in “Chinese Journal of Dermatology”

This study observed that skin dryness does not seem to indicate impaired epidermal barrier function, as there was no negative correlation between stratum corneum water content and transepidermal water loss.

research Epidermal Vascular Endothelial Growth Factor Production Is Required for Permeability Barrier Homeostasis, Dermal Angiogenesis, and the Development of Epidermal Hyperplasia

100 citations , August 2008 in “American Journal Of Pathology”

This study found that epidermal VEGF is crucial for maintaining skin barrier function in mice and may help explain psoriasis development following skin trauma due to its effects on angiogenesis and hyperplasia.

research 856 Topical application of newly developed pseudoceramide improved both skin and hair barrier functions

April 2017 in “Journal of Investigative Dermatology”

Applying pseudoceramide improved skin and hair health.

research Human tissue kallikreins as promiscuous modulators of homeostatic skin barrier functions

84 citations , May 2008 in “Biological Chemistry”

This review discusses the roles of human tissue kallikreins in skin physiology and pathology and reports no new findings, emphasizing their potential involvement in various skin functions and conditions.

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Community Join

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community Peptides that Stop Hair Loss? | In-depth Literature Review Video

76 upvotes 2 years ago

Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.

community Switching RU vehicle due to scalp irritation – anyone tried low-EtOH + squalane / emu oil?

in Treatment 2 upvotes 9 months ago

The user is experiencing scalp irritation from using RU58841 with a 70% ethanol and 30% propylene glycol vehicle and is considering switching to a less irritating vehicle, such as 30% ethanol with 70% squalane or emu oil. They are seeking feedback on the effectiveness and irritation levels of these alternative carriers.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community Why is no one talking about this? Topical dutasteride out performs oral finasteride.

in Finasteride/Dutasteride 180 upvotes 1 year ago

Topical dutasteride is considered more effective for hair regrowth with fewer side effects than oral finasteride. Users have mixed experiences, with some preferring topical applications for reduced side effects.

community Wtf have we been doing for the last 30 years

in Treatment 548 upvotes 1 year ago

Hair loss treatments like finasteride, minoxidil, and dutasteride work but have side effects. A permanent cure is still not available due to the complexity of hair loss and limited investment.

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Learn

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learn Tretinoin

Vitamin A retinoid cream, prescribed for acne

learn oleic acid

Is Oleic Acid safe to apply directly to the scalp, or should it be used in a formula? Oleic acid loosens the skin's lipid barrier, and studies link it to flaking in dandruff-prone people. Its effects on the scalp, neat or in formulas, have not been tested in trials.

learn Linoleic Acid

Does linoleic acid reduce scalp irritation that can worsen hair loss? Linoleic acid is part of the skin barrier, but no human study shows that applying it reduces scalp irritation or slows hair loss.
How does linoleic acid work on the scalp when used in shampoos or oils? Linoleic acid is part of the skin's lipid barrier, and lab studies link it to hair-growth signals. No human trial shows that shampoos or oils containing it improve hair growth.

learn Jojoba oil

Can jojoba oil reduce scalp irritation or dryness that makes hair fall out more easily? Jojoba oil is used to moisturise dry skin, and a review of plant oils describes it as a possible option for a damaged skin barrier. No study shows that it reduces scalp irritation or hair loss.

learn Glycerin

What role does glycerin play in scalp hydration and overall hair health? Glycerin is a humectant that draws water into the outer skin layer; small skin studies show better hydration and barrier repair, but the scalp evidence comes only from multi-ingredient products.

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Experts

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SMP Specialist
Noelle Skin
Nice, France

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