Human Tissue Kallikreins as Promiscuous Modulators of Homeostatic Skin Barrier Functions

May 2008 in “ Biological Chemistry ”

Azza Eissa, Eleftherios P. Diamandis

human tissue kallikreins KLKs serine protease endopeptidases skin barrier functions KLK5 KLK7 hair follicles skin desquamation antimicrobial defense lipid permeability skin inflammation pigmentation tumor suppression proteinase-activated receptor signaling

TLDR Human tissue kallikreins help regulate skin barrier functions and affect skin health.

The document reviewed the roles of human tissue kallikreins (KLKs), a family of serine protease endopeptidases, in skin barrier functions. It highlighted that KLKs, particularly KLK5 and KLK7, were initially recognized for their proteolytic activity in the skin, but recent findings suggested broader roles through proteolytic activation cascades. These enzymes were proposed to modulate various skin functions, including desquamation, antimicrobial defense, and lipid permeability. Additionally, evidence indicated their involvement in skin inflammation, pigmentation, and tumor suppression by targeting proteinase-activated receptor signaling pathways. The review summarized the current understanding of KLKs in skin physiology and pathobiology.

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research Human Tissue Kallikreins as Promiscuous Modulators of Homeostatic Skin Barrier Functions

84 citations , May 2008 in “Biological Chemistry”

Human tissue kallikreins help regulate skin barrier functions and affect skin health.