research KLK5 and KLK7 Ablation Fully Rescues Lethality of Netherton Syndrome-Like Phenotype
Removing both KLK5 and KLK7 proteins can prevent death and skin issues in Netherton syndrome.
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5 / 47 results research LB1256 TRIV-509, A Dual Inhibitor of KLK5 and KLK7, Rapidly Improves Barrier Integrity and Markers of Epidermal Differentiation in Atopic Dermatitis Skin Explants
TRIV-509 quickly improves skin barrier and cell health in atopic dermatitis.
research Systemic Treatment with a KLK5 Inhibitor Shows Efficacy in a Murine Model of Netherton Syndrome
A KLK5 inhibitor effectively improved skin symptoms in a mouse model of Netherton Syndrome.
research Single- And Multiple-Ascending Dose Studies Of DS-2325a, A KLK5 Inhibitor For The Treatment Of Netherton Syndrome
DS-2325a is safe and well-tolerated, supporting further development for Netherton Syndrome treatment.
research Human Tissue Kallikreins as Promiscuous Modulators of Homeostatic Skin Barrier Functions
Human tissue kallikreins help regulate skin barrier functions and affect skin health.
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