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research Human tissue kallikreins as promiscuous modulators of homeostatic skin barrier functions

84 citations , May 2008 in “Biological Chemistry”

This review discusses the roles of human tissue kallikreins in skin physiology and pathology and reports no new findings, emphasizing their potential involvement in various skin functions and conditions.

research Tissue Regeneration, Stem Cells, and Wound Healing

3 citations , January 2012 in “Journal of Investigative Dermatology”

Inhibiting PGD2 and using dermal papilla cells may improve skin and hair regeneration.

Long-Term Prophylaxis With Androgens in the Management of Hereditary Angioedema in Emerging Countries

research Long-term Prophylaxis with Androgens in the management of Hereditary Angioedema (HAE) in emerging countries

November 2022 in “Orphanet Journal of Rare Diseases”

This review discusses treatment options for hereditary angioedema and reports no new results; it highlights concerns about androgen side effects and mentions approved alternatives with fewer serious adverse effects.

research The role of vasoactive peptides in skin homeostasis—focus on adiponectin and the kallikrein-kinin system

8 citations , February 2023 in “American Journal of Physiology-Cell Physiology”

This review discusses the roles of adiponectin and bradykinin in skin homeostasis and pathologies, highlighting the need for further research into their therapeutic potential but reports no new clinical results.

research Protease activity, localization and inhibition in the human hair follicle

11 citations , August 2013 in “International Journal of Cosmetic Science”

This study found that a combination of Trichogen and climbazole may inhibit protease activity and increase the force required to remove human hair, suggesting potential to reduce excessive hair shedding.

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community Verteporfin Phase 1 Human Clinical Trial In The Works - Research

92 upvotes 1 year ago

Verteporfin is being discussed for its potential to regrow hair and heal scars, possibly aiding hair transplants or replacing them. Some users are skeptical about its effectiveness, while others suggest combining it with microneedling for better results.

community Is it possible to transplant mice skin into human body?

in Transplants 47 upvotes 10 months ago

Transplanting mice skin to humans is not feasible due to immune rejection, but some suggest genetic modification or immune suppression could make it possible. Xenograft hair transplants are discouraged.

community Protective effects of taurine on human hair follicle grown in vitro. - PubMed

4 upvotes 7 years ago

Taurine promotes hair survival and protects hair follicles. Users discuss trying topical taurine for hair growth.

community 5 alpha reductase type 1 is in brain tissue producing the main endogenous gabaergic allopregnanolone, not 2. How can finasteride as a 5ar2 lower that?

27 upvotes 1 year ago

Finasteride and dutasteride are discussed for hair loss, with concerns about their effects on neurosteroids and potential side effects like depression. Alternatives like topical estrogen and lifestyle changes are considered, with varying opinions on mental health and hair regrowth.

community So we have 20k dollars human like machines available but no new effective treatment for hairloss since finasteride :)

in Chat 237 upvotes 1 year ago

There have been no new effective hair loss treatments since finasteride, despite technological advancements. Current treatments include finasteride, minoxidil, and RU58841, with ongoing challenges and potential future solutions in research.

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Learn

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learn RU58841

RU58841: Is it safe or does it have strange side effects? (Because no one wants unpleasant surprises) There is no published human safety study of RU58841: the evidence is animal and tissue work only, human absorption has never been measured, and the side effects users describe are self-reported with unverified product.

learn Osteopontin

Is Osteopontin more effective in topical treatments or oral supplements for hair loss? Neither route has been tested: there is no published human trial of topical or oral osteopontin for hair loss. The evidence is preclinical, and it points both ways — injected osteopontin promoted hair growth in mice, while an osteopontin-derived peptide suppressed growth in human scalp tissue and is being developed to remove unwanted hair.

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