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Glossary Permeation Studies

measure substance passage through barriers like skin or membranes

Permeation studies are scientific tests used to measure how substances, such as drugs or chemicals, pass through a barrier, like skin or a membrane. These studies are crucial in fields like dermatology and pharmacology to understand how effectively a treatment can penetrate the skin and reach its target area.

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Development and Ex-Vivo Skin Permeation Studies of Finasteride–Poly(Lactic Acid-Co-Glycolic Acid) and Minoxidil–Chitosan Nanoparticulate Systems

research Development and ex-vivo skin permeation studies of finasteride–poly(lactic acid-co-glycolic acid) and minoxidil–chitosan nanoparticulate systems

12 citations , March 2020 in “Journal of Bioactive and Compatible Polymers”

This study found that finasteride- and minoxidil-loaded nanoparticles in a gel improved skin permeability and drug retention, suggesting a promising approach for topical alopecia treatment with reduced dosing frequency and side effects.

research Simple and Selective HPLC-UV/Vis Bioanalytical Method to Determine Aluminum Phthalocyanine Chloride in Skin Permeation Studies

8 citations , January 2018 in “Journal of Analytical Methods in Chemistry”

This study developed a reliable HPLC-UV/Vis method to determine aluminum phthalocyanine chloride in skin, supporting its use in skin permeation studies for photodynamic therapy of cutaneous tumors.

Targeting Potential of Zinc Oxide Nanoparticles and Finasteride-Loaded Nano Lipidic Carriers-Infused Topical Gel: In Vitro and In Vivo Skin Permeation Studies

research Targeting Potential of Zinc Oxide Nanoparticles and Finasteride-loaded Nano Lipidic Carriers-infused Topical Gel - In vitro and In vivo Skin Permeation Studies

November 2023

In this study, researchers developed a novel gel formulation combining zinc oxide nanoparticles and finasteride-loaded nanostructured lipid carriers, which showed promising results for topical delivery and effective skin penetration, potentially offering a new treatment approach for androgenic alopecia.

research Fabrication of Thymoquinone and Ascorbic Acid-Loaded Spanlastics Gel for Hyperpigmentation: In Vitro Release, Cytotoxicity, and Skin Permeation Studies

4 citations , January 2025 in “Pharmaceutics”

This study found that spanlastic gel loaded with thymoquinone and ascorbic acid improved skin deposition and tyrosinase inhibition, suggesting potential as a treatment for hyperpigmentation.

New Insight for Enhanced Topical Targeting of Caffeine for Effective Cellulite Treatment: In Vitro Characterization, Permeation Studies, and Histological Evaluation in Rats

research New Insight for Enhanced Topical Targeting of Caffeine for Effective Cellulite Treatment: In Vitro Characterization, Permeation Studies, and Histological Evaluation in Rats

7 citations , October 2024 in “AAPS PharmSciTech”

This study developed a caffeine-loaded solid lipid nanoparticle gel, observing significant reduction in subcutaneous fat tissue thickness in histological tests compared to an untreated group, suggesting it could effectively treat cellulite as a promising nanocosmeceutical gel.

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community sharing my experience using Fin/Dut + minoxidil to treat alopecia.

31 upvotes 1 week ago

Using finasteride/dutasteride with minoxidil can help stop hair loss and regrow some hair, but stopping minoxidil may lead to rapid shedding. Unrealistic expectations can affect perception of treatment effectiveness.

community Marijuana and hair loss?

6 upvotes 10 years ago

The conversation discusses the potential impact of marijuana on hair loss, with some users suggesting it may worsen hair loss due to hormonal changes, while others believe it might alter perception rather than cause actual thinning. The original poster uses Propecia (finasteride) and Rogaine (minoxidil) for treatment and is considering quitting marijuana to see if it affects hair health.

community What I hate about being told to shave my head

in Chat 258 upvotes 1 year ago

Hair loss challenges and identity issues, with opinions on using finasteride, minoxidil, and hair transplants versus accepting baldness. Some find shaving more work, while others stress personal choice and self-perception.

community Why liposomal finasteride and minoxidil may be better than traditional topical solutions.

in Research/Science 2 upvotes 1 year ago

Liposomal formulations of finasteride and minoxidil may enhance drug delivery to the skin and hair follicles more effectively than traditional solutions, potentially improving treatment outcomes. However, more human clinical trials are needed to confirm these benefits.

community What’s your views on clascoterone 5% topical solution by cosmo

23 upvotes 9 months ago

Clascoterone 5% topical solution shows promise for treating male-pattern hair loss by blocking DHT at the follicle without systemic absorption, potentially offering fewer side effects than oral treatments like finasteride. While results are promising, long-term safety and effectiveness need further study, and it may serve as a starting point for developing more effective treatments.

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