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    Glossary Purinergic Signaling

    cell communication using purines like ATP to regulate functions

    Purinergic signaling refers to the communication system in the body that uses purines, such as ATP (adenosine triphosphate), as signaling molecules. These purines bind to specific receptors on cell surfaces, known as purinergic receptors, to regulate various physiological processes, including inflammation, pain perception, and tissue repair. This type of signaling is crucial in many biological functions and is being studied for its potential therapeutic applications in conditions like chronic pain and neurodegenerative diseases.

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      research EMATOPOIESIS REVOLVES AROUND THE PRIMORDIALEVOLUTIONAL RHYTHM OF INNATE IMMUNITY AND PURINERGIC SIGNALING – A JOURNEY TO THE DEVELOPMENTAL ROOTS

      January 2024 in “Wiadomości Lekarskie”
      This study highlights the role of innate immunity and purinergic signaling in regulating hematopoiesis and hematopoietic stem/progenitor cell specification. The researchers observed that these ancient pathways operate both paracrinally and autocrinally within HSPCs, maintaining their developmental function throughout evolution.

      research 780 Novel mechanism of UVB-mediated pigmentation through the axis of ATP-P2X7

      April 2019 in “˜The œjournal of investigative dermatology/Journal of investigative dermatology”
      This study demonstrates that extracellular ATP induced by UV radiation promotes melanin production in human melanocytes, suggesting ATP-induced purinergic signaling may influence skin pigmentation.

      research MULTIOMICS – A NEW EXCITING ERA OF RESEARCH

      January 2024 in “Wiadomości Lekarskie”
      In this study, researchers at the Laboratory of Regenerative Medicine WUM are exploring the long-term effects of SARS-CoV-19 infection, focusing on stem cell mobilization and engraftment processes, and utilizing advanced diagnostic techniques to develop algorithms for rare disease classification, including amyloidosis.

      research Critical Role of ATP-P2X7 Axis in UV-Induced Melanogenesis

      23 citations , March 2019 in “˜The œjournal of investigative dermatology/Journal of investigative dermatology”
      This study found that extracellular ATP released from UVB-irradiated keratinocytes promotes melanin production through the P2X7 receptor, indicating a role for ATP-P2X7 signaling in UV-induced melanogenesis.