Hematopoiesis Revolves Around the Primordial Evolutionary Rhythm of Innate Immunity and Purinergic Signaling – A Journey to the Developmental Roots

The document discusses the role of primordial evolutionary signals and pathways, specifically innate immunity and purinergic signaling, in regulating cell metabolism, organogenesis, and tissue development. These ancient pathways, involving components like the complement cascade and ATP, maintain cell integrity by balancing reactive oxygen and nitrogen species. While low levels of these species support cell growth, high levels can cause damage. Despite the evolution of new regulatory factors like growth factors and cytokines, these primordial pathways continue to influence hematopoiesis and the specification of hematopoietic stem/progenitor cells (HSPCs), functioning both paracrinally and autocrinally. Recent laboratory evidence supports their ongoing regulatory role in hematopoiesis.