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GlossarySkin Permeability

ability of substances to pass through skin layers

Skin permeability refers to the ability of substances to pass through the skin barrier. This is important for the delivery of medications through topical treatments and for understanding how chemicals in the environment can affect the body. Factors like the condition of the skin, the size and solubility of the substance, and the presence of enhancers or barriers can influence how easily substances penetrate the skin.

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community Peptides that Stop Hair Loss? | In-depth Literature Review Video

in Research/Science 73 upvotes 4 months ago

Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.

community Topical finasteride now the safest possible path?

in Finasteride/Dutasteride 76 upvotes 4 months ago

Topical finasteride is considered a safer option for hair regrowth with fewer systemic side effects compared to oral finasteride. Some users report similar efficacy and side effects between topical and oral treatments, while others prefer topical due to reduced systemic exposure.

community Sandalore: a scientific homemade approch

20 upvotes 6 years ago

The post discusses using Sandalore as a potential hair loss treatment, emphasizing precise measurements and safe handling. The user compares Sandalore's effects to Minoxidil and mentions preparing a solution with ethanol and DMSO.

community I am a dermatologist with a clinical interest in alopecia. AMA

in Will treatment work for me? 2 years ago

In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

community Countering oral minoxidil side effects by taking collagen supplements?

in Minoxidil 16 upvotes 5 months ago

Oral minoxidil may deplete collagen, potentially causing skin aging. Users discuss whether taking collagen supplements can counteract this effect.

community Anyone tried Tretinoin? I’ve heard great things

in Treatment 23 upvotes 9 months ago

People discuss using Tretinoin for both skin anti-aging and improving hair loss treatments. They mention combining Tretinoin with Minoxidil to enhance its effectiveness for hair growth.

community Does seborrheic dermatitis block absorption of topicals?

in Treatment 10 upvotes 1 year ago

User wonders if seborrheic dermatitis blocks absorption of topicals for hair loss. They use nizoral to improve the condition but it's not fully gone.

community Best Ketoconozole shampoo that doesn’t dry out hair?

in Ketoconazole 11 upvotes 1 week ago

People are discussing ketoconazole shampoos that don't dry out hair, with suggestions including using it as a topical treatment, switching to T-Sal, and using moisturizing products like hyaluronic acid serum and biotin conditioner. Regenepure DR is confirmed to still contain ketoconazole, and some users recommend using moisturizing shampoos and conditioners to prevent dryness.

community Is microneedling + minoxidil better than oral minoxidil

in Chat 28 upvotes 3 weeks ago

Oral minoxidil is considered more effective for hair regrowth than topical minoxidil, but it carries higher risks. Combining microneedling with topical minoxidil can enhance absorption, but oral minoxidil with microneedling shows significant results.

community i got more results 1 month 5 mg oral minoxidil and 1 mg dutasteride then i did 6 months on finasteride and topical minoxidil

in Finasteride/Dutasteride 49 upvotes 8 months ago

A user reported better hair regrowth with 5 mg oral minoxidil and 1 mg dutasteride than with finasteride and topical minoxidil, calling topical minoxidil a scam. Replies varied, with some defending topical minoxidil, questioning the user's application method, and suggesting that previous treatments might be contributing to the observed results.

community Procyanidin B2 Topical Serum - The Cheap, Complete(ish) DIY Formula

in Research/Science 6 upvotes 1 year ago

The conversation is about a homemade hair loss treatment serum containing Procyanidin B2, Aloe Vera Gel, Coconut Oil, Castor Oil, and Rosemary Essential Oil. The main concern is finding an affordable source of Procyanidin B2 and ensuring its stability in the serum at room temperature.

community Tretinoin, any good, what’s your experience

in Research/Science 22 upvotes 5 months ago

The conversation discusses using tretinoin for hair loss and skincare. Users share experiences, noting tretinoin's effectiveness in combination with minoxidil for hair and its proven benefits for anti-aging skincare.

community How long have you tried topical melatonin?

in Treatment 4 upvotes 8 months ago

The conversation is about the effectiveness of topical melatonin for hair loss, asking for details on dosage, frequency, duration of use, results, and brand information. An update includes a skeptical view on the studies regarding melatonin's effectiveness.

community Derm made me a topical finasteride solution but I'm sceptical

in Finasteride/Dutasteride 2 upvotes 11 months ago

A dermatologist prescribed a topical hair loss treatment containing finasteride, biotin, melatonin, and caffeine without alcohol. The user is skeptical about its effectiveness.

community Do you guys wait 24 hours before applying minoxidil after dermarolling [.5 mm]?

in Microneedling 12 upvotes 1 year ago

The conversation discusses whether to wait 24 hours before applying minoxidil after using a .5 mm dermaroller for hair loss treatment. The specific treatments mentioned are microneedling, minoxidil, and dermarolling.

community New Study and Product: Tomorrowlabs HSF

in Research/Science 8 upvotes 1 year ago

New product Tomorrowlabs HSF targets hair loss through HIF pathway indirectly by removing scalp iron. Minoxidil and Stemoxydine also relate to HIF pathway.

community Comprehensive Microneedling Guide

in Microneedling 293 upvotes 2 years ago

Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

community 6 week update fellas, 5mg oral minoxidil. Pics are 2nd June – 10th July

in Progress Pictures 2 years ago

, you can find it online with a script This user was discussing their progress with hair loss treatments including 5mg oral Minoxidil and combining 3mg oral Minoxidil with MTF HRT. They also discussed side effects of increased body hair in other parts of the body.

community Topical T3 study - 1000% Growth. Anyone tried it?

in Research/Science 106 upvotes 3 years ago

The conversation discusses using T3 (triiodothyronine) as a topical treatment for hair growth, with some users noting it showed promising results in studies but lacked follow-up. Users express interest in trying T3 due to its potential effectiveness compared to Minoxidil.

community Topical Dutasteride is Here.

in Finasteride/Dutasteride 153 upvotes 3 years ago

The availability of Topical Dutasteride, a potential treatment for hair loss, which can be purchased without prescription from MinoxidilMax. Other treatments discussed include Topical Finasteride and PRP injections, with discussion around dosage, efficacy, side-effects and safety.

community 2 months topical dutasteride plus minoxidil, very happy with the results!

in Finasteride/Dutasteride 337 upvotes 3 years ago

A user's success in treating their hair loss with 2x daily topical dutasteride and minoxidil, as well as the potential for using less frequent application of topical dutasteride due to its long half-life.

community Why nobody uses 0.25% (2.5mg/ml)?

in Treatment 65 upvotes 10 months ago

The conversation is about the effectiveness of 0.25% topical finasteride compared to other concentrations and forms. Users discuss its potential for better scalp DHT reduction and fewer side effects, with some preferring topical over oral treatments.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 3 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community M21 I stopped finesterid 3 Months ago... this is how it looks now

in Finasteride/Dutasteride 176 upvotes 5 months ago

A user stopped finasteride due to side effects and rapid hair loss, considering a hair system. Others suggested alternatives like dutasteride, minoxidil, and topical finasteride.

community How is there still no consensus on Topical Dutasteride in 2024?

in Finasteride/Dutasteride 145 upvotes 6 months ago

The conversation expresses frustration over the lack of clear evidence regarding the effectiveness and systemic impact of topical Dutasteride for hair loss treatment, despite years of discussion. People are criticized for not conducting proper research and for providing contradictory anecdotal claims.

community Finally Managed to Download Somebody's Alex pdf so try to share it

in Research/Science 70 upvotes 9 months ago

The conversation discusses a shared PDF about hair loss treatments, which might help those not seeing results with Minoxidil, Finasteride, and RU58841. Some users are skeptical about the content's value and the price charged for it.

community Transformation from balding to…

in Progress Pictures 1856 upvotes 1 year ago

The user, Lofi-luu, shared their transformation from balding to having a full head of hair after getting a hair transplant and using finasteride for almost 2 years. They also discussed their workout routine and emphasized the importance of not letting balding hold them back in life.

community pictures before I started pyrilutamide (repost)

in Progress Pictures 124 upvotes 1 year ago

Automatic-Law-3612's progress with hair loss treatments, including topical finasteride, topical dutasteride, minoxidil and pyrilutamide. They have been using these products for two weeks and noticed baby hairs in their temples getting longer.

community The truth about Dutasteride (w/ sources)

in Finasteride/Dutasteride 52 upvotes 1 year ago

The effectiveness of Dutasteride compared to Finasteride in treating hair loss, with evidence given such as studies and experiences, as well as discussion around whether one should switch from Finasteride to Dutasteride. There is also a discussion on post-Dutasteride syndrome.

community Reddit’s Amatorial microneedling meta analysis of 11 different Clinical studies for a Total of 559 patients (Scalp microneedling + topical minoxidil 5%, safety, efficacy and Ideal protocol)

in Microneedling 329 upvotes 2 years ago

Microneedling with 5% minoxidil improves hair growth for hair loss patients. Best protocol: 1.5mm dermaroller weekly for 12 weeks or 0.6mm dermapen every 2 weeks for 12 weeks, skipping topicals for 24 hours.