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research 863 Central centrifugal cicatricial alopecia gene expression analysis revealed cholesterol, fatty acid, and mast cell pathways

April 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

In this study, researchers found that CCCA in women of African descent is associated with molecular changes, including dysregulation of fatty acid metabolism and fibrosis pathways, suggesting potential targets for new treatments.

research Primary cicatricial alopecias are characterized by dysregulation of shared gene expression pathways

19 citations , July 2022 in “PNAS Nexus”

This study identified a shared gene signature in scarring alopecia subtypes, with increased mast cell presence, suggesting similar treatment approaches may be effective across these hair loss disorders.

research 865 Frontal fibrosing alopecia is associated with dysregulation of cholesterol biosynthesis pathways, fibrosis and mast cells

April 2019 in “Journal of Investigative Dermatology”

This study found that frontal fibrosing alopecia involves distinct molecular changes, such as downregulation of steroid and cholesterol pathways and upregulation of fibrotic and immune response genes, which may help guide treatment strategies.

research Investigation of hub genes and immune infiltration in androgenetic alopecia using bioinformatics analysis

November 2022 in “Annals of Translational Medicine”

This study identified four hub genes that are closely linked to the causative factors of androgenetic alopecia, suggesting potential diagnostic and therapeutic targets.

research Mast cell hyperplasia in the skin of Dsg4-deficient hypotrichosis mice, which are long-living mutants of lupus-prone mice

7 citations , August 2008 in “Immunogenetics”

A gene mutation in mice causes increased mast cells and disorganized hair follicles in their skin.

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learn Stem Cell Factor

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community Trying to understand finasteride side effects and post finasteride syndrome

70 upvotes 5 years ago

The conversation discusses the side effects of finasteride, including low libido and erectile dysfunction, and the possibility of these effects being permanent, known as post-finasteride syndrome (PFS). Some users report personal experiences with PFS and debate whether the condition is real, with varying opinions on the reversibility of side effects and the role of individual biology.

community What are your unpopular opinions on hair loss and its treatments?

59 upvotes 1 year ago

Hair loss treatments like finasteride, minoxidil, and hair transplants are more accessible and effective now. Concerns about side effects and skepticism about new treatments like hair cloning and GT20029 remain.

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Hair System Specialist
Jane Genesi
Marlton, PA, United States

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Jane Genesi