The Inflammatory Aspect of Male and Female Pattern Hair Loss

    November 2020 in “ DOAJ (DOAJ: Directory of Open Access Journals) ”
    Peyravian N, Deo S, Sylvia Daunert, Jimenez JJ
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    TLDR Inflammation plays a key role in male and female pattern hair loss, and focusing on this could help develop better treatments.
    The paper "The Inflammatory Aspect of Male and Female Pattern Hair Loss" discusses the role of inflammation in male and female pattern hair loss (MPHL and FPHL), which affects nearly 80 million people in the US. The authors highlight evidence of inflammation as a characteristic feature of MPHL and FPHL, supported by clinical and quantitative data. The data suggests the presence of significant perifollicular inflammatory infiltrates, such as lymphocytes and histiocytes, and the involvement of inflammatory genes, such as CASP7 and TNF, in the presentation of MPHL and FPHL. The authors suggest that focusing on the inflammatory aspect in MPHL and FPHL pathogenesis could advance future developments in therapeutic options.
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