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GlossaryPerifollicular Infiltrate

accumulation of immune cells around hair follicles

Perifollicular infiltrate refers to the accumulation of immune cells around hair follicles. This can be a sign of inflammation or an immune response, often seen in conditions like alopecia areata, where the body's immune system mistakenly attacks hair follicles, leading to hair loss.

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Perifollicular Inflammation and Fibrosis in Androgenetic Alopecia: Implications for Diagnosis and Treatment - A Comparative Histopathologic and Clinical Study with Normal-Appearing Scalp

research Perifollicular Inflammation and Fibrosis in Androgenetic Alopecia: Implications for Diagnosis and Treatment - A Comparative Histopathologic and Clinical Study with Normal-Appearing Scalp

January 2026 in “Clinical Cosmetic and Investigational Dermatology”

Early diagnosis and targeted anti-inflammatory treatments can improve outcomes in androgenetic alopecia with perifollicular inflammation and fibrosis.

research The Inflammatory Aspect of Male and Female Pattern Hair Loss

November 2020 in “DOAJ (DOAJ: Directory of Open Access Journals)”

Inflammation plays a key role in male and female pattern hair loss, and focusing on this could help develop better treatments.

Low-Level Light Therapy Downregulates Scalp Inflammatory Biomarkers in Men With Androgenetic Alopecia and Boosts Minoxidil 2% for Sustainable Hair Regrowth

research Low-Level Light Therapy Downregulates Scalp Inflammatory Biomarkers in Men With Androgenetic Alopecia and Boosts Minoxidil 2% for Sustainable Hair Regrowth

4 citations , May 2021 in “Lasers in Surgery and Medicine”

Light therapy reduces scalp inflammation, boosts hair regrowth with Minoxidil 2%.

research Inflammatory Phenomena and Fibrosis in Androgenetic Alopecia

1 citations , January 2010 in “Springer eBooks”

Hair loss in androgenetic alopecia may be due to ongoing tiny inflammation and tissue changes around hair follicles.

research Unveiling a Shared Precursor Condition for Acne Keloidalis Nuchae and Primary Cicatricial Alopecias

1 citations , August 2023 in “Clinical, Cosmetic and Investigational Dermatology”

A condition with certain scalp changes may come before acne keloidalis nuchae and other similar hair loss disorders.

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community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community The MPB itch aka DHT itch is very real.

in Chat 9 upvotes 3 years ago

Hair loss itch is caused by DHT attacking follicles and stimulating nerves. Finasteride users who respond well don't experience this itch.

community DHT Harms Scalp Microbiome: DHT Itch is REAL

in Research/Science 409 upvotes 10 months ago

Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.

community Perifollicular Fibrosis and its role in androgenetic alopecia. Is Aminexil/Kopexil a must for anyone with AGA?

in Research/Science 4 upvotes 3 years ago

Aminexil/Kopexil may help reduce hair loss by addressing perifollicular fibrosis in androgenetic alopecia, but it lacks the extensive clinical backing of finasteride and minoxidil. Some users find it effective, but availability and cost are issues, especially in the US where it's not FDA-approved.

community How I started reversing Male Pattern Baldness naturally ?

in Question 8 upvotes 8 years ago

The user reversed male pattern baldness using a pro-thyroid diet, lifestyle changes, and scalp stimulation exercises, without Minoxidil or Finasteride. They reported reduced dandruff, itchiness, oiliness, and experienced hair regrowth and thickening over 15 months.

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