Expression of the L-Fucose Moiety on Infrainfundibular Follicular Keratinocytes of Terminal Follicles, Its Decreased Expression on Vellus and Indeterminate Follicles of Androgenetic Alopecia, and Re-Expression in Drug-Induced Hair Regrowth

    January 1992 in “ Journal of Investigative Dermatology ”
    Madalene C.Y. Heng, Scott Levine, Harriet Fine, Suni G. Allen, Ming K. Heng
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    TLDR Sugar molecule helps hair growth, less in balding, returns with treatment.
    This study from 31 years ago found that the L-fucose moiety, a sugar molecule, is expressed on keratinocytes in terminal hair follicles but is decreased in vellus and indeterminate follicles of androgenetic alopecia. However, drug-induced hair regrowth resulted in the re-expression of the L-fucose moiety. The study suggests that the L-fucose moiety may play a role in hair growth and could be a potential target for hair loss treatments.
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