Expression of the L-Fucose Moiety on Infrainfundibular Follicular Keratinocytes of Terminal Follicles, Its Decreased Expression on Vellus and Indeterminate Follicles of Androgenetic Alopecia, and Re-Expression in Drug-Induced Hair Regrowth

January 1992 in “ Journal of Investigative Dermatology ”

Madalene C.Y. Heng, Scott Levine, Harriet Fine, Suni G. Allen, Ming K. Heng

L-fucose moiety keratinocytes terminal hair follicles vellus follicles indeterminate follicles androgenetic alopecia drug-induced hair regrowth sugar molecule hair growth hair loss treatments

TLDR Sugar molecule helps hair growth, less in balding, returns with treatment.

This study from 31 years ago found that the L-fucose moiety, a sugar molecule, is expressed on keratinocytes in terminal hair follicles but is decreased in vellus and indeterminate follicles of androgenetic alopecia. However, drug-induced hair regrowth resulted in the re-expression of the L-fucose moiety. The study suggests that the L-fucose moiety may play a role in hair growth and could be a potential target for hair loss treatments.

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