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Spontaneous Intrinsic Aging in Organ-Cultured Human Skin as a Novel Ex Vivo Assay to Test Anti-Aging Actives

research 581 Spontaneous, Intrinsic Aging in Organ-Cultured Human Skin as Novel Ex Vivo Assay to Test Candidate Anti-Aging Actives

November 2022 in “Journal of Investigative Dermatology”

This study reported that an ex vivo organ culture system effectively induced aging-related changes in healthy human skin, allowing testing of senolytics like tretinoin, resveratrol, and caffeine.

research Dermal adipose tissue has high plasticity and undergoes reversible dedifferentiation in mice

136 citations , September 2019 in “Journal of Clinical Investigation”

This study found that mature dermal adipocytes have high plasticity, undergoing dedifferentiation and redifferentiation, which plays a significant role in hair cycling and wound healing.

Clonal Growth of Dermal Papilla Cells in Hydrogels Reveals Intrinsic Differences Between Sox2-Positive and Sox2-Negative Cells In Vitro and In Vivo

research Clonal Growth of Dermal Papilla Cells in Hydrogels Reveals Intrinsic Differences between Sox2-Positive and -Negative Cells In Vitro and In Vivo

68 citations , December 2011 in “Journal of Investigative Dermatology”

This study reported that a three-dimensional hydrogel culture system supports the growth and maintenance of distinct dermal papilla cell types, crucial for skin reconstitution assays in neonatal mice.

research STAT3 Partly Inhibits Cell Proliferation via Direct Negative Regulation of FST Gene Expression

3 citations , June 2021 in “Frontiers in genetics”

This study found that STAT3 directly inhibited the activity of the sheep FST gene promoter, consequently reducing cell proliferation and promoting a better understanding of hair follicle development mechanisms.

research 0950 Exploring hair aging through ex vivo induction of DNA damage and senescence

July 2025 in “Journal of Investigative Dermatology”

BrdU speeds up hair follicle aging and reduces hair quality.

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Community Join

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community Polydopamine Synergizes with Quercetin Nanosystem to Reshape the Perifollicular Microenvironment for Accelerating Hair Regrowth in Androgenetic Alopecia.

11 upvotes 2 years ago

A quercetin-encapsulated and polydopamine-integrated nanosystem (PDA@QLipo) shows promise for treating androgenetic alopecia by reshaping the perifollicular microenvironment, outperforming minoxidil in hair regeneration. The nanosystem promotes cell proliferation, hair follicle renewal, and recovery by scavenging reactive oxygen species and enhancing neovascularity.

community Weed/THC effects on hair growth/hair loss, and vitality of organ-culture human follicle studies (research review)

4 upvotes 1 year ago

Cannabis and THC may have mixed effects on hair, with some studies suggesting potential negative impacts on hair growth in isolated hair follicles, but these results are hard to apply to living humans. Treatments like minoxidil and finasteride are commonly used for hair loss, and the effects of cannabis might be neutral or vary based on individual factors.

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learn KY19382

compound that activates Wnt/β-catenin to promote hair regrowth and create new hair follicles

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21
Hair Transplant Surgeon
Jian Mingcheng, 中華民國皮膚科專科醫師, 台灣美容醫學醫學會教育委員, ISHRS 世界植髮醫學會, AAHRS 亞洲植髮醫學會
Taipei, Taiwan

Jian Mingcheng, 中華民國皮膚科專科醫師, 台灣美容醫學醫學會教育委員, ISHRS 世界植髮醫學會, AAHRS 亞洲植髮醫學會