The Potential of Spirulina Maxima Extract-Treated Conditioned Medium From Adipose-Derived Mesenchymal Stem Cells for Hair Growth Promotion on Human Dermal Papilla Cells

    March 2025 in “ Regenerative Therapy
    Seung Tae Im, Su Jin Heo, Eun-A. Kim, Nalae Kang, Soo-Jin Heo, Seung‐Hong Lee
    TLDR Spirulina maxima extract may help hair growth by boosting cell activity.
    The study examines the potential of Spirulina maxima extract-treated conditioned medium (SACM) from adipose-derived mesenchymal stem cells (ADMSCs) to enhance hair growth in human dermal papilla cells (HDPCs). Spirulina maxima extract boosts the secretion of growth factors like FGF, HGF, and VEGF from ADMSCs, which are vital for hair growth. SACM significantly increases cell proliferation and alkaline phosphatase activity in HDPCs, promoting hair growth in vitro by activating the mTOR/Akt and Wnt/β-catenin signaling pathways. The results suggest that SACM could be an effective regenerative therapy for hair growth, with potential applications in the pharmaceutical and cosmeceutical industries. Further research is recommended to identify the active components of Spirulina maxima extract and compare its effects with existing hair growth treatments.
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