Elucidation of the Potential Hair Growth-Promoting Effect of Botryococcus Terribilis, Its Novel Compound Methylated-Meijicoccene, and C32 Botryococcene on Cultured Hair Follicle Dermal Papilla Cells Using DNA Microarray Gene Expression Analysis

May 2022 in “ Biomedicines ”

Aprill Kee Oliva, Meriem Bejaoui, Atsushi Hirano, Takashi Arimura, Tran Ngoc Linh, Eriko Uchiage, Sachiko Nukaga, Kazuhiro Tominaga, Hiroyuki Nozaki, Hiroko Isoda

Botryococcus terribilis methylated-meijicoccene C32 botryococcene hair follicle dermal papilla cells collagen synthesis keratin synthesis inflammation reduction

TLDR Botryococcus terribilis and its compounds may promote hair growth and improve hair health.

The study investigated the hair growth-promoting effects of the green alga Botryococcus terribilis and its compounds, methylated-meijicoccene and C32 botryococcene, on hair follicle dermal papilla cells. The research found that both types of cells from Botryococcus terribilis stimulated the expression of several pathways and genes associated with hair growth, collagen and keratin synthesis, and inflammation reduction. The compounds methylated-meijicoccene and C32 botryococcene, isolated from Botryococcus terribilis, showed promising effects on hair growth without any cytotoxic effect on the cells. This is the first evidence of the hair growth promoting effect of Botryococcus terribilis and its novel compounds.

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