Hair Multiplication With Dermal Papilla-Like Tissue Containing Human Dermal Papilla Cells

June 2014 in “ Biotechnology and Bioprocess Engineering ”

Bo-Young Yoo, Youn-Ho Shin, Hee‐Hoon Yoon, Young‐Kwon Seo, Jung‐Keug Park

TLDR Injecting lab-grown hair cells into the scalp can regrow hair.

The study investigated a novel hair cell therapy for alopecia using bioartificial dermal papilla tissue. Researchers created dermal papilla-like tissues (DPLTs) from cultured human dermal papilla cells (DPCs) and tested their hair-inducing ability in vivo with a modified hair sandwich model. Injecting DPLTs into mouse scalp skin led to new hair growth at the injection site within 2-3 weeks, with human cells from DPLTs and Outer Root Sheath Cells (ORSCs) present in the new hair. The results indicated that DPLTs could be useful for in vitro hair development studies, drug testing, and as an alternative for hair transplantation.

View this study on link.springer.com →

Discuss this study in the Community →

Research cited in this study

20 / 20 results

research Comparison of Hair Dermal Cells and Skin Fibroblasts in a Collagen Sponge for Use in Wound Repair

5 citations , August 2011 in “Biotechnology and Bioprocess Engineering”

research Improved Isolation of Outer Root Sheath Cells from Human Hair Follicles and Their Proliferation Behavior Under Serum-Free Condition

13 citations , February 2007 in “Biotechnology and Bioprocess Engineering”

research Molecular Principles of Hair Follicle Induction and Morphogenesis

479 citations , January 2005 in “BioEssays”

Hair follicle development is controlled by interactions between skin tissues and specific molecular signals.

research Expression Profiles of Tyrosine Kinases in Cultured Follicular Papilla Cells Versus Dermal Fibroblasts

11 citations , July 2004 in “Journal of Investigative Dermatology”

Certain tyrosine kinases may regulate hair growth and could help develop hair loss treatments.

research Molecular Control of Epithelial-Mesenchymal Interactions During Hair Follicle Cycling

277 citations , June 2003 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings”

Epithelial-mesenchymal interactions control hair growth cycles through specific molecular signals.

research In Vivo Promoted Growth of Mice Hair Follicles by the Controlled Release of Growth Factors

60 citations , April 2003 in “Biomaterials”

Controlled release of growth factors in hydrogels improved hair growth in mice.

research Simple and Rapid Method to Isolate and Culture Follicular Papillae from Human Scalp Hair Follicles

78 citations , August 2002 in “Experimental Dermatology”

Researchers developed a quick and easy way to get and grow cells from the base of human hair follicles.

research Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis

520 citations , February 2001 in “Journal of Clinical Investigation”

VEGF helps hair grow and determines follicle size by increasing blood vessel growth.

research Hepatocyte Growth Factor Activator Expressed in Hair Follicles Is Involved in In Vitro HGF-Dependent Hair Follicle Elongation

77 citations , February 2001 in “Journal of Dermatological Science”

HGF activator helps convert HGF to its active form, promoting hair growth.

research Changing Patterns of Localization of Putative Stem Cells in Developing Human Hair Follicles

87 citations , February 2000 in “Journal of Investigative Dermatology”

Stem cells in developing hair follicles move to specific areas as they mature.

research Differences in Hair Follicle Dermal Papilla Volume Are Due to Extracellular Matrix Volume and Cell Number: Implications for the Control of Hair Follicle Size and Androgen Responses

231 citations , December 1999 in “Journal of Investigative Dermatology”

Hair follicle size is mainly influenced by the number of cells and extracellular matrix volume, with cell number having a larger impact.

research Hair Matrix Germinative Epidermal Cells Confer Follicle-Inducing Capabilities on Dermal Sheath and High Passage Papilla Cells

61 citations , October 1996 in “Development”

Hair growth can be stimulated by combining certain skin cells, which can rejuvenate old cells and cause them to specialize in hair follicle creation.

research Dermal-Epidermal Interactions in Hair Follicle Development and Maintenance

114 citations , October 1996 in “Dermatologic clinics”

Hair loss is mainly caused by hormones, autoimmune issues, and chemotherapy, and needs more research for treatments.

research Experimental Approaches for the Reconstitution of Hair In Vitro

6 citations , January 1994 in “Skin Pharmacology and Physiology”

Dermal papillae are crucial for hair growth and follicle development.

research Induction of Follicle Formation and Hair Growth by Vibrissa Dermal Papillae Implanted into Rat Ear Wounds: Vibrissa-Type Fibres Are Specified

125 citations , August 1992 in “Development”

Implanted dermal papillae can induce hair growth in rat ear wounds.

research Dermal-Epidermal Interactions in Hair Follicle Development and Cycling

65 citations , October 1988 in “Clinics in dermatology”

The dermal papilla interacts with the epidermis to control hair growth and development.

research Collagen-Type Synthesis in Human Hair Papilla Cells in Culture

28 citations , April 1988 in “Archives of Dermatological Research”

Effects of Epidermal Growth Factor, Fibroblast Growth Factor, Minoxidil, and Hydrocortisone on Growth Kinetics in Human Hair Bulb Papilla Cells and Root Sheath Fibroblasts Cultured In Vitro

research Effects of Epidermal Growth Factor, Fibroblast Growth Factor, Minoxidil, and Hydrocortisone on Growth Kinetics in Human Hair Bulb Papilla Cells and Root Sheath Fibroblasts Cultured In Vitro

58 citations , June 1987 in “Archives of Dermatological Research”

EGF and FGF boost hair cell growth, hydrocortisone slows it, and minoxidil doesn't affect it.

research The In Vitro Properties of Dermal Papilla Cell Lines Established From Human Hair Follicles

106 citations , April 1986 in “British Journal of Dermatology”

Dermal papilla cells from human hair follicles form unique structures and don't live as long as other skin cells in lab conditions.

research Immunohistochemical Localization of Basement Membrane Components During Hair Follicle Morphogenesis

59 citations , March 1984 in “Journal of Investigative Dermatology”

Related Community Posts Join

6 / 1000+ results

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community Han Bio claims success at Hair Multiplication

in Research/Science 19 upvotes 4 years ago

Han Bio claims success in hair multiplication using dermal papilla cells. Treatments discussed include Minoxidil, finasteride, and RU58841.

community Han Bio Planning Hair Multiplication Trial This Year?

in Technology 6 upvotes 4 years ago

Han Bio plans to start clinical trials for a new hair multiplication technology this year, which could significantly reduce the cost and time of hair transplantation. The technology uses a single hair strand to cultivate enough cells for 30,000 hair strands.

community Epibiotech will now offer off-the-shelf allogeneic hair multiplication treatment in South Korea

in Research/Science 81 upvotes 3 years ago

Epibiotech will offer off-the-shelf allogeneic hair multiplication treatment in South Korea, using dermal papilla cells from donors to grow hair in balding areas. This method is cheaper and less invasive than traditional hair transplants.

community Hair Multiplication Projects in China - Promising clinical trial results on Mice

in Technology 36 upvotes 6 months ago

A breakthrough in hair follicle cultivation using induced pluripotent stem cells (iPSCs) has been achieved, producing large hair follicles suitable for transplantation. Clinical trials for this hair multiplication technology are planned in partnership with Yinguan Biotechnology.

community HairClone: Good info from their site

in Technology 10 upvotes 3 years ago

HairClone aims to rejuvenate miniaturizing hair follicles through follicle banking and cell expansion, with treatments potentially available in the UK by 2022. The process involves extracting, storing, and cloning hair follicles, but full regenerative treatments will take many years to develop.

Related Research

5 / 5 results

research Sisaipho Alopecia Areata Treated With Tofacitinib and Oral Minoxidil

1 citations , August 2022 in “JAAD case reports”

Tofacitinib and oral minoxidil may help treat Sisaipho alopecia areata.

research Review of Hair Follicle Dermal Cells

321 citations , December 2009 in “Journal of Dermatological Science”

Dermal cells are key in controlling hair growth and could potentially be used in hair loss treatments, but more research is needed to improve hair regeneration methods.