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research The development of an in vitro human hair follicle organoid with a complexity similar to that in vivo

February 2024 in “Biomedical materials”

This study developed a new human in vitro hair model that replicates in vivo hair characteristics and may be suitable for high throughput screening of hair growth treatments.

research From in-vitro to in-vivo: Corporate development and efficacy of a topical hair growth agent derived from natural extracts

2 citations , January 2009

This article reviews the development of a topical hair growth agent using natural extracts and reports no new clinical results, emphasizing the need for further evaluation of its efficacy.

research Regulation of Hair Follicle Development: An In Vitro Model for Hair Follicle Invasion of Dermis and Associated Connective Tissue Remodeling.

30 citations , July 1993 in “Journal of Investigative Dermatology”

In Vitro and In Vivo Models for the Development of Hair Growth Materials by Regulating the β-Catenin Signaling Pathways

research In Vitro</i> and In Vivo* Models for the Development of Hair Growth Materials By Regulating the β-Catenin Signaling Pathways*

February 2024 in “Journal of medicinal food”

This study reports that the β-catenin inhibitor tegatrabetan reduced hair growth and hair follicle numbers in mice, suggesting its potential as a model for developing new hair growth materials.

Utilization of Response Surface Design for Development and Optimization of Rosuvastatin Calcium-Loaded Nano-Squarticles for Hair Growth Stimulating VEGF and IGF Production: In Vitro and In Vivo Evaluation

research Utilization of response surface design for development and optimization of rosuvastatin calcium-loaded nano-squarticles for hair growth stimulating VEGF and IGF production: in-vitro</i> and in-vivo* evaluation*

1 citations , September 2023 in “Drug development and industrial pharmacy”

In this study, researchers developed and optimized squarticles containing rosuvastatin calcium and found that they promoted hair regrowth in rats within 10 days, showing superior results compared to the standard minoxidil treatment.

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Community Join

5 / 97 results

community Re:you (NOVOGRO) New Hair Loss Treatment Coming in August

45 upvotes 2 months ago

NOVOGRO's new hair loss treatment is questioned for its effectiveness compared to minoxidil, with skepticism about its claims and trial results. The product targets women and lacks the 5α-reductase inhibitor NV-1065, which is still in development.

community We should actually be hopeful for these recent new developments

112 upvotes 1 year ago

AI advancements, like AlphaFold, are speeding up drug discovery for hair loss, promising more effective treatments. Current options like minoxidil and finasteride have limitations, but new developments could improve solutions in 5-10 years.

community P-1075: a BETTER version of Minoxidil

11 months ago

P-1075 is a more potent hair growth agent than Minoxidil, but it poses significant heart risks, making it unsafe for use. Despite promising results in macaques, concerns about its cardiotoxicity in rats have halted its development.

community We already know how to permanently fix hair loss. The science is done. The only thing missing is the funding to run one experiment.

in Technology 613 upvotes 4 months ago

A permanent hair loss solution could involve reprogramming hair follicles to resist DHT using mRNA and siRNA. However, high costs, safety concerns, and the pharmaceutical industry's preference for ongoing treatments over one-time cures are major obstacles, with finasteride and minoxidil remaining standard treatments.

community Genomic Sequencing for Hair Loss

in Research/Science 156 upvotes 5 months ago

Hair loss treatments like Minoxidil, finasteride, and potential mRNA therapies are discussed. There is skepticism about targeting specific genes due to the complex genetic nature of hair loss.

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Learn

8 / 11 results

learn Exosomes

Microscopic delivery system that sends growth-promoting signals to hair follicles

learn Overview

learn Stem Cell Factor

learn Beta Polypeptide

learn Thymosin Beta 4

learn SCUBE3

How does SCUBE3 work on hair follicles compared to treatments like minoxidil or finasteride? Laboratory research in mice reports that SCUBE3, a protein released by dermal papilla cells, signals dormant follicles to grow through the TGF-β pathway downstream of Hedgehog; minoxidil and finasteride instead work on blood flow to the follicle and on DHT, and unlike SCUBE3 they have decades of human trial data behind them. SCUBE3 has not been tested in human clinical trials and is not available as a medicine.

learn Vascular Endothelial Growth Factor

Can products that stimulate Vascular Endothelial Growth Factor (VEGF) improve blood flow to hair follicles? Yes, products that stimulate VEGF may improve blood flow to hair follicles.

learn Azelaic Acid

Is azelaic acid a treatment on its own or does it need supplements? One small randomised trial (26 women) found 5% azelaic acid comparable to 2% minoxidil in female pattern hair loss, and the anti-DHT rationale otherwise rests on in-vitro work — community members generally describe azelaic acid as an add-on to minoxidil or finasteride rather than a standalone treatment.

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Clinics

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Experts

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SMP Specialist
Hairo Fallas
Newark, NJ, United States

Hairo Fallas