Utilization of Response Surface Design for Development and Optimization of Rosuvastatin Calcium-Loaded Nano-Squarticles for Hair Growth Stimulating VEGF and IGF Production: In Vitro and In Vivo Evaluation

    September 2023 in “ Drug development and industrial pharmacy ”
    Mervat S. Ibrahim, Nihal Mohamed Elmahdy Elsayyad, Abeer Salama, Shereen H. Noshi
    Studysummary In this study, researchers developed and optimized squarticles containing rosuvastatin calcium and found that they promoted hair regrowth in rats within 10 days, showing superior results compared to the standard minoxidil treatment.
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    Research cited in this study 18

    1. A Treatment Combination of IGF and EGF Promotes Hair Growth in the Angora Rabbit Genes · 2020
    2. Spray-Dried Rosuvastatin Nanoparticles for Promoting Hair Growth AAPS PharmSciTech · 2020
    3. Topical Minoxidil-Loaded Nanotechnology Strategies for Alopecia Cosmetics · 2020
    4. Novel Drug Delivery Approaches for the Management of Hair Loss Expert opinion on drug delivery · 2020
    5. The Effect of Particle Size on the Deposition of Solid Lipid Nanoparticles in Different Skin Layers: A Histological Study Advanced Pharmaceutical Bulletin · 2016
    6. Anti-PDGF Receptor β Antibody-Conjugated Squarticles Loaded with Minoxidil for Alopecia Treatment by Targeting Hair Follicles and Dermal Papilla Cells Nanomedicine: Nanotechnology, Biology and Medicine · 2015
    7. Drug Discovery for Alopecia: Gone Today, Hair Tomorrow Expert Opinion on Drug Discovery · 2015
    8. Telogen Effluvium: A Review Journal of Clinical and Diagnostic Research · 2015
    9. Follicular Delivery of Spironolactone via Nanostructured Lipid Carriers for Management of Alopecia International Journal of Nanomedicine · 2014
    10. Delivery and Targeting of Nanoparticles into Hair Follicles Therapeutic Delivery · 2014
    11. Nanotechnology in Dermatology Anais Brasileiros De Dermatologia · 2014
    12. Squarticles as a Lipid Nanocarrier for Delivering Diphencyprone and Minoxidil to Hair Follicles and Human Dermal Papilla Cells Aaps Journal · 2013
    13. Preparation and Characterization of Minoxidil Loaded Nanostructured Lipid Carrier Gel for Effective Treatment of Alopecia Journal of The Saudi Pharmaceutical Society · 2013
    14. Squalene-Containing Nanostructured Lipid Carriers Promote Percutaneous Absorption and Hair Follicle Targeting of Diphencyprone for Treating Alopecia Areata Pharmaceutical Research · 2012
    15. Human Hair Follicle: Reservoir Function and Selective Targeting British Journal of Dermatology · 2011
    16. Techniques for the Discovery and Evaluation of Drugs Against Alopecia Expert Opinion on Drug Discovery · 2011
    17. Hair Growth Defects in Insig-Deficient Mice Caused by Cholesterol Precursor Accumulation and Reversed by Simvastatin ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2010
    18. Follicular Transport Route: Research Progress and Future Perspectives European journal of pharmaceutics and biopharmaceutics · 2009

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    1. Promoted Growth of Murine Hair Follicles Through Controlled Release of Vascular Endothelial Growth Factor Biomaterials · 2002