From In-Vitro to In-Vivo: Corporate Development and Efficacy of a Topical Hair Growth Agent Derived from Natural Extracts

In 2009, researchers developed a topical hair growth agent using a blend of natural extracts aimed at treating androgenetic alopecia, which affects up to 50% of the global population. The study focused on influencing hair growth by targeting vascular endothelial and keratinocyte growth factors, inhibiting the proteasome complex, and regulating the cytokine IE-1a. Botanical extracts were selected through in-vitro cell culture and enzyme assays using an arbitrary scoring system. An optimized blend of Eichochalcone, Saw Palmetto, Shiso, and Green Rooibos was created using Design of Experiments analysis, which included analyses of variance and multiple linear regressions. The resulting formulation, encapsulated with liposomes, passed human irritancy and sensitization tests and demonstrated long-term stability. The final product underwent a clinical-type trial to evaluate its efficacy in increasing scalp hair growth, although the document does not provide the results or the number of participants involved in the trial.