TLDR Future drugs targeting specific hair growth steps could improve treatments for hair growth issues.
The document reviewed the control of hair growth, focusing on the role of stem cells in the hair follicle, particularly in the basal layer of the outer root sheath and the bulge area. These stem cells migrate to the hair matrix, where they divide and differentiate, a process regulated by cytokines from dermal papilla cells. Androgens influenced hair growth indirectly by affecting cytokine synthesis and release. The study also discussed drugs affecting hair growth, including cytotoxic drugs, antiandrogens, and those acting on potassium channels, suggesting that future drug development targeting specific steps in hair growth could improve treatment for hair growth disorders.
January 2016 in “프로그램북(구 초록집)” Hormones and neuropeptides affect hair growth, with androgens having opposite effects on beard and scalp hair.
122 citations
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November 2010 in “Journal of Dermatological Science” Male pattern baldness involves hormones and cell signals affecting hair growth.
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95 citations
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July 2006 in “British Journal of Dermatology” Vitamin D receptors in hair follicles change with the hair cycle, affecting hair growth.
130 citations
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June 2003 in “Journal of Investigative Dermatology Symposium Proceedings” Estrogen Receptor ß (ERß) is the main hormone controller in human skin and hair follicles, not Estrogen Receptor α (ERα) or the Androgen Receptor (AR).
229 citations
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August 2002 in “Experimental Gerontology” AGA causes hair loss by shrinking hair follicles due to DHT binding, and can be treated with finasteride and minoxidil.
173 citations
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July 1995 in “Biochemical and biophysical research communications” Male hormones promote hair cell growth by using a growth factor from nearby skin cells.
