Regulation of Human Hair Growth: Hormones and Neuropeptides
January 2016
in “
프로그램북(구 초록집)
”
androgens beard growth androgenetic alopecia testosterone dihydrotestosterone 5a-reductase androgen receptors IGF-1 TGF-b Wnt/b-catenin signaling estrogens 17β estradiol hair matrix cell differentiation neuropeptides substance P calcitonin gene-related peptide anagen phase AGA DHT 5-alpha reductase insulin-like growth factor 1 transforming growth factor beta CGRP SP
TLDR Hormones and neuropeptides affect hair growth, with androgens having opposite effects on beard and scalp hair.
The document discussed the regulation of human hair growth by hormones and neuropeptides, highlighting the androgen paradox where androgens stimulate beard growth but suppress hair growth in androgenetic alopecia (AGA). Human hair follicles can form active androgens like testosterone and dihydrotestosterone (DHT), with 5a-reductase and androgen receptors playing key roles. Androgens regulate hair growth by influencing mediators like IGF-1 and TGF-b, and involve crosstalk with Wnt/b-catenin signaling. Estrogens, such as 17β estradiol, inhibit DHT formation and promote hair matrix cell differentiation, showing different effects in humans and animals. Neuropeptides like substance P and calcitonin gene-related peptide (CGRP) also affect hair growth, with SP promoting and CGRP inhibiting the anagen phase.
