Human Scalp Hair: Modulation by Various Factors and Hormones - Do Estrogens Inhibit or Stimulate? A Perplexing Perspective

    February 2019 in “ Journal of Cosmetic Dermatology
    Edwin D. Lephart
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    TLDR The effects of estrogen on human scalp hair growth are unclear and need more research.
    The document reviews the ambiguous effects of 17ß-estradiol, a potent sex steroid hormone, on human scalp hair growth, acknowledging the controversy over whether it stimulates or inhibits hair follicles. It examines the roles of various estrogen receptors, the negative impact of 5α-reductase and its product 5α-DHT, and the potential influences of steroidogenesis. The paper also discusses the interaction between estrogen-related receptor gamma and phytochemicals, the role of aromatase in androgenetic alopecia treatment, and the variable effectiveness of 5α-reductase inhibitors in female pattern hair loss. Additionally, it touches on the changes in hair growth during and after pregnancy and the formation of estrogens in hair follicles. The conclusion calls for more research to understand the complex interactions of estrogens on hair growth. The author, Edwin D. Lephart, was solely responsible for the concept, research, and writing of the article and reported no conflicts of interest.
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