Estrone Sulfate Source of Estrone and Estradiol Formation in Isolated Human Hair Roots: Identification of a Pathway Linked to Hair Growth Phase and Subject to Site, Gender, and Age-Related Modulations

The study explored the role of estrogen formation from estrone sulfate in human hair roots, finding that it was linked to the hair growth phase and influenced by gender and age. The research indicated that the in situ synthesis of estrogen from estrone sulfate and the selective halt of estradiol synthesis at the end of the hair cycle were crucial in regulating hair growth. This suggested that the pathway of estrogen formation played a significant role in the modulation of hair growth, with variations observed based on site, gender, and age.