A Review of the Role of Estrogen in Dermal Aging and Facial Attractiveness in Women

February 2018 in “ Journal of cosmetic dermatology ”

Edwin D. Lephart

estrogen androgens estrogen hormone therapy oral conjugated equine estrogens skin health menopause facial attractiveness circulating estrogens hormonal influences CEE

Studysummary This review explores how estrogens influence skin health and attractiveness in women, particularly with aging, but it reports no new clinical findings. Our plain-language summary of this paper — not a Tressless recommendation.

The review discussed the significant role of estrogens in maintaining skin health and facial attractiveness in women. Estrogens, which peak in the mid- to late 20s and decline significantly by age 50 and post-menopause, positively influenced dermal health, perceived age, attractiveness, and facial coloration. Estrogen hormone therapy, such as oral conjugated equine estrogens (CEE), was shown to restore skin health. The review highlighted the importance of hormonal influences on dermal health and youthful appearance, particularly from a psychological dermato-endocrine perspective. The author declared no conflict of interest.

View this study on onlinelibrary.wiley.com →

Discuss this study in the Community →

Research cited in this study

6 / 6 results

research Estrogens and Aging Skin

150 citations , April 2013 in “Dermato-endocrinology”

This review discusses the effects of estrogen on skin aging and highlights potential therapies, but reports no new clinical findings.

research Analysis of the MicroRNA Expression Profile of Normal Human Dermal Papilla Cells Treated with 5α-Dihydrotestosterone

22 citations , March 2012 in “Molecular Medicine Reports”

This study found that DHT treatment led to reduced cell growth, increased cell death, cell cycle arrest, ROS production, and senescence in normal human dermal papilla cells, potentially mediated by altered miRNA expression.

research Sexual Hormones in Human Skin

305 citations , February 2007 in “Hormone and metabolic research”

This review discusses the roles of androgens and estrogens in skin functions and disorders, and highlights the use of estrogen-progestin treatments and anti-androgens in managing hirsutism and acne, without reporting new results.

research Biology of Estrogens in Skin: Implications for Skin Aging

187 citations , December 2005 in “Experimental Dermatology”

This article discusses the role of estrogens in skin aging and reports no new findings; it highlights the potential of selective ER modulators to improve skin health without systemic side effects.

research Localization of Sex Steroid Receptors in Human Skin

147 citations , April 2004 in “PubMed”

This study identifies specific localization patterns of androgen, estrogen, and progesterone receptors in human skin, which could be crucial for understanding their roles in skin biology and pathology.

The Distribution of Estrogen Receptor Beta Is Distinct to That of Estrogen Receptor Alpha and the Androgen Receptor in Human Skin and the Pilosebaceous Unit

research The Distribution of Estrogen Receptor Beta Is Distinct to That of Estrogen Receptor Alpha and the Androgen Receptor in Human Skin and the Pilosebaceous Unit

130 citations , June 2003 in “Journal of Investigative Dermatology Symposium Proceedings”

This study found that estrogen receptor beta, not alpha, is the main mediator of estrogen action in human skin and hair follicles, suggesting a distinct role in these tissues.