TLDR DHEA may help with sexual function when used intravaginally by menopausal women but is similar to hormone therapy in other aspects and might cause more side effects like acne and hair loss.
The 2015 review analyzed the impact of dehydroepiandrosterone (DHEA) on peri- or postmenopausal women, focusing on sexual function, quality of life, menopausal symptoms, and side effects compared to hormone therapy (HT). It found that while oral DHEA did not significantly improve sexual function, intravaginal DHEA showed some benefits. There was no significant difference between DHEA and HT in enhancing quality of life or alleviating menopausal symptoms. Side effects such as acne and hair loss were more common with DHEA than HT, but these findings were not statistically significant. The review suggests that intravaginal DHEA might be beneficial for sexual function, but in other respects, it is comparable to HT and may increase the risk of certain side effects.
48 citations,
July 2009 in “The Journal of Sexual Medicine” DHEA did not improve sexual function, well-being, or menopausal symptoms in postmenopausal women with low libido but caused side effects like acne and increased facial hair.
46 citations,
May 2009 in “Maturitas” Taking DHEA for a year is generally safe for postmenopausal women but may cause acne and more facial hair without improving metabolism or aging.
254 citations,
September 2014 in “Menopause” The NAMS 2014 recommendations guide healthcare providers on treating health issues in midlife women, emphasizing individualized care and informed decision-making.
32 citations,
March 2019 in “Climacteric” Premature ovarian insufficiency (POI) can harm women's sexual health, and they may benefit from hormone therapy and counseling.
9 citations,
November 2008 in “Journal of Womens Health” Researchers had trouble finding enough participants for a trial on DHEA's effects on postmenopausal women's sexual desire.
59 citations,
August 2004 in “Human Reproduction Update” Testosterone replacement can help women with low libido and mood, but they need to have enough estrogen first to avoid side effects.
8 citations,
February 2009 in “Current Women's Health Reviews” Testosterone treatment can improve sexual function and bone density in women but may have adverse effects and requires more research on safety and guidelines.
