Testosterone Treatment in Women: An Overview

The document from 2009 discusses testosterone treatment in women, with a focus on postmenopausal and oophorectomized women who may experience androgen deficiency. Testosterone has been shown to improve psychosexual function, well-being, bone density, and body composition, and is beneficial for sexual function when added to estrogen/progestogen therapy. However, it may also reduce HDL cholesterol and has potential adverse metabolic effects. The only approved form of testosterone treatment by the EMEA as of 2006 is the testosterone patch for sexual dysfunction in oophorectomized women. The document calls for more research on optimal doses, side effects, and long-term safety, as well as guidelines for treatment indications and diagnosis of female androgen insufficiency. Concerns are raised about the potential risks of testosterone therapy, including virilization and effects on the breast and endometrium, and the need for evidence-based research to understand the benefits and risks of androgen replacement therapy in women.