The Rationale for Physiological Testosterone Replacement in Women

The document from 1998 provides a comprehensive overview of the role of testosterone in women's health and the potential benefits of testosterone replacement therapy. It explains that testosterone is important for various physiological functions, including sexual function, bone mass development, and body composition. The decline in testosterone levels with age can lead to symptoms that affect quality of life, and replacement therapy may improve sexual motivation, bone mineral density, and muscle mass in post-menopausal women. The paper also discusses the use of testosterone in specific conditions like premature ovarian failure and PMS, and acknowledges the need for individualized therapy and further research to establish clear guidelines. While there are potential risks associated with testosterone replacement, such as cardiovascular disease and virilization, these are considered unlikely with physiological dosing and proper monitoring. The document concludes that testosterone replacement can be beneficial for women with androgen insufficiency, but more research is needed to fully understand its benefits and risks.