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research Estrogen hormone therapy stabilizes lateral hairline in transfeminine patients: Implications for facial feminization surgery

1 citations , July 2024 in “Journal of Plastic Reconstructive & Aesthetic Surgery”

In this study, older age was found to predict lateral hairline recession in TGNB AMAB individuals, while each year of feminizing hormone therapy in patients over 30 also predicted a decrease in lateral forehead length by 0.07 cm.

research Treatment of hirsutism with a gonadotropin-releasing hormone agonist and estrogen replacement therapy

19 citations , March 1994 in “Fertility and sterility”

This study found that treatment with a GnRH agonist and estrogen and progestin replacement significantly improved hirsutism scores and hair growth rates in women with polycystic ovarian disease.

Priorities for Efficacy Trials of Gender-Affirming Hormone Therapy With Estrogen: Collaborative Design and Results of a Community Survey

research Priorities for efficacy trials of gender-affirming hormone therapy with estrogen: collaborative design and results of a community survey

February 2024 in “Hormones”

This study surveyed individuals seeking estrogen-based gender-affirming hormone therapy, revealing that improving life satisfaction and femininity are top treatment goals, and highlighting the need for trials aligned with community priorities.

research The Safety of Local Hormonal Treatment for Vulvovaginal Atrophy in Women With Estrogen Receptor-positive Breast Cancer Who Are on Adjuvant Aromatase Inhibitor Therapy: Meta-analysis

18 citations , August 2019 in “Clinical breast cancer”

This meta-analysis found that in postmenopausal women with a history of breast cancer, 8 weeks of vaginal estrogen therapy while on aromatase inhibitors did not result in systemic absorption of sex hormones, suggesting potential safety for treating vulvovaginal atrophy in this context.

research Dermatological effects of menopausal hormone therapy: A path to overcoming hormone phobia

May 2026 in “Meditsinskiy sovet = Medical Council”

This review outlines the benefits of menopausal hormone therapy for improving skin properties in peri- and postmenopausal women, emphasizing that interdisciplinary management enhances quality of life but noting the aesthetic improvements are secondary outcomes.

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Community Join

5 / 793 results

community 9 months fin/dut + topical min + estrogen. Doing a happy dance!

148 upvotes 1 year ago

The post discusses a user's successful hair regrowth using finasteride, dutasteride, topical minoxidil, and estrogen over nine months. The user, who is male-to-female (mtf), reports significant regrowth and no side effects beyond typical hormone replacement therapy effects.

community Hair recovery after 7 years since the start of balding

3 upvotes 3 weeks ago

A user started balding at 17 and began hormone therapy with cyproterone and estrogel, along with minoxidil, which helped regrow hair at the front but not the back. Another user shared their experience of limited regrowth with dutasteride and minoxidil, noting that longer periods of hair loss make recovery more difficult.

community do i need finasteride if im already taking oral spironolactone? (hrt)

in Transgender 2 upvotes 1 year ago

The conversation is about managing hair loss while on hormone replacement therapy (HRT) with estrogen and spironolactone. The user considers adding finasteride but decides to wait and see the effects of the current treatment.

community 19 months Topical Min/Fin - 7 months HRT

1072 upvotes 3 months ago

The user experienced significant hair regrowth and fullness after starting hormone replacement therapy (HRT) with sublingual estrogen and spironolactone, in addition to using a topical solution of minoxidil, finasteride, ketoconazole, and biotin. They noted initial shedding phases but emphasized that shedding is a sign of future growth.

community (MTF 35) Results of 18 Months of HRT

775 upvotes 8 months ago

A transgender woman experienced significant hair regrowth after 18 months of hormone replacement therapy (HRT) with estrogen and bicalutamide. The discussion notes HRT's effectiveness for hair regrowth but warns against its use for cisgender men due to feminizing effects.

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Learn

6 / 6 results

learn Estradiol

an estrogen promoting hair regrowth more commonly used in women

How does topical Estradiol compare to oral Estradiol in treating alopecia? Topical estradiol delivers hormone to the scalp with less systemic exposure, but evidence is thin and it is still a hormone. It needs a doctor's supervision, and people with estrogen-sensitive cancers must not use it without medical approval.
Why is Estradiol used to treat hair loss in women and transgender people undergoing hormone therapy? Estradiol helps treat hair loss by balancing hormones and supporting hair follicle health.

learn Alfatradiol

a synthetic estrogen used topically as an anti-androgen

Alfatradiol: What does a form of estrogen have to do with hair loss in men? Alfatradiol (17α-estradiol) is a prescription topical hormone, licensed for androgenetic alopecia in Germany but not FDA-approved. The controlled trial evidence is in women, where it produced stabilisation rather than regrowth and was outperformed by minoxidil; no comparable placebo-controlled trial in men appears to have been published.

learn Cyproterone

a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor

learn Overview

learn Dutasteride

Heavy duty finasteride that comes with higher risks

learn Clascoterone

Can I use clascoterone if I'm undergoing gender-affirming hormone therapy? No published clinical trial has tested clascoterone in people on gender-affirming hormone therapy, so its safety in that group is unknown. The FDA label reports low systemic exposure and no described effect on blood testosterone, but it also records HPA-axis suppression and raised potassium in a small minority of subjects.

Clinics

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