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    Glossary Paracrine Function

    cells communicate by releasing signals to nearby cells

    Paracrine function refers to a type of cell signaling where a cell produces a signal to induce changes in nearby cells, affecting their behavior or function. Unlike hormones that travel through the bloodstream to distant targets, paracrine signals act locally, ensuring that the response is limited to the immediate cellular environment. This is crucial in processes like wound healing and immune responses.

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    1. Fibrous scaffolds potentiate the paracrine function of mesenchymal stem cells: A new dimension in cell-material interaction Biomaterials · 2017 · 182 citations
    2. Effects of microenvironment and biological behavior on the paracrine function of stem cells Genes & Diseases · 2023 · 44 citations
    3. The topography of fibrous scaffolds modulates the paracrine function of Ad-MSCs in the regeneration of skin tissues Biomaterials Science · 2019 · 24 citations
    4. Melatonin membrane receptors in peripheral tissues: Distribution and functions Molecular and Cellular Endocrinology · 2012 · 506 citations
    5. Biomaterials Functionalized with MSC Secreted Extracellular Vesicles and Soluble Factors for Tissue Regeneration Advanced functional materials · 2020 · 220 citations
    6. Emerging nonmetabolic functions of skin fat Nature Reviews Endocrinology · 2018 · 65 citations
    7. Keratinocytes regulate the function of melanocytes 2014 · 55 citations
    8. [Genetic dissection of retinoic acid function in epidermis physiology]. PubMed · 2002 · 9 citations
    9. Prolactin Signaling Influences the Timing Mechanism of the Hair Follicle: Analysis of Hair Growth Cycles in Prolactin Receptor Knockout Mice* Endocrinology · 2001 · 73 citations
    10. Stem cell secretome as a new booster for regenerative medicine Bioscience trends · 2019 · 54 citations
    11. Exploring pericyte and cardiac stem cell secretome unveils new tactics for drug discovery Pharmacology & Therapeutics · 2016 · 26 citations
    12. Prolactin Signaling Influences the Timing Mechanism of the Hair Follicle: Analysis of Hair Growth Cycles in Prolactin Receptor Knockout Mice Endocrinology · 2001 · 14 citations
    13. The Localization of Cytokeratin 19 and Vimentin in Sprague Dawley Albino Rat Skin Tissue Applied Microscopy · 2014 · 1 citations
    14. Effective and economical cell therapy for hair regeneration Biomedicine & Pharmacotherapy · 2022 · 17 citations
    15. Transplanted hair follicle mesenchymal stem cells alleviated small intestinal ischaemia–reperfusion injury via intrinsic and paracrine mechanisms in a rat model Research Square (Research Square) · 2022
    16. Effects of Hydrogels on Mesenchymal Stem/Stromal Cells Paracrine Activity and Extracellular Vesicles Production Journal of Extracellular Vesicles · 2025 · 21 citations
    17. RGDSP-functionalized peptide hydrogel stimulates growth factor secretion via integrin αv/PI3K/AKT axis for improved wound healing by human amniotic mesenchymal stem cells Frontiers in Bioengineering and Biotechnology · 2024 · 6 citations
    18. Is Dihydrotestosterone a Classic Hormone? Endocrine Reviews · 2017 · 4 citations
    19. Transplanted hair follicle mesenchymal stem cells alleviated small intestinal ischemia–reperfusion injury via intrinsic and paracrine mechanisms in a rat model Frontiers in Cell and Developmental Biology · 2022 · 6 citations
    20. Human Scalp Hair Follicles Are Both a Target and a Source of Prolactin, which Serves as an Autocrine and/or Paracrine Promoter of Apoptosis-Driven Hair Follicle Regression American Journal of Pathology · 2006 · 128 citations
    21. 1376 Dermal white adipose tissue enhances proliferation, pigmentation and hair shaft elongation in human hair follicles ex vivo Journal of Investigative Dermatology · 2018
    22. Applications of Mesenchymal Stem Cells in Anti-Aging and Skin Regeneration MedScien · 2026
    23. Multifunctional Merkel cells: Their roles in electromagnetic reception, finger-print formation, Reiki, epigenetic inheritance and hair form Medical hypotheses · 2010 · 23 citations
    24. The Central Role of Fibroblasts in Androgenic Alopecia: a systematic umbrella review and meta-meta-analysis Open MIND · 2026
    25. The Use of Stem Cells in Plastic and Reconstructive Surgery Advances in Clinical and Experimental Medicine · 2014 · 31 citations
    26. Author response: Crosstalk with keratinocytes causes GNAQ oncogene specificity in melanoma 2021
    27. Decision letter: Crosstalk with keratinocytes causes GNAQ oncogene specificity in melanoma 2021
    28. Conditioned media derived from mesenchymal stem cell cultures: The next generation for regenerative medicine Journal of Tissue Engineering and Regenerative Medicine · 2019 · 88 citations
    29. Insulin-like growth factor 1 and hair growth Dermatology Online Journal · 1999 · 98 citations
    30. HB-EGF Improves the Hair Regenerative Potential of Adipose-Derived Stem Cells via ROS Generation and Hck Phosphorylation International Journal of Molecular Sciences · 2019 · 20 citations