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      The Senescence-Like Activity of BMS-470539 Is Associated With Anti-Fibrotic Actions in Models of Dermal Fibrosis

      research The senescence-like activity of BMS-470539 is associated with anti-fibrotic actions in models of dermal fibrosis

      September 2025 in “Arthritis Research & Therapy”
      In this study, researchers found that the compound BMS-470539 induced a senescence-like state in fibroblasts from systemic sclerosis patients, reducing fibrosis-associated markers in vitro and decreasing skin thickness in a mouse model of skin fibrosis, suggesting a novel therapeutic strategy for managing fibroblast-driven diseases.
      Frontal Fibrosing Alopecia: A Review of 60 Cases

      research Frontal fibrosing alopecia: A review of 60 cases

      166 citations , April 2012 in “Journal of The American Academy of Dermatology”
      This study reviewed clinical data from 60 patients with frontal fibrosing alopecia and found increasing prevalence and generally poor response to treatment, with the cause remaining unclear.
      Frontal Fibrosing Alopecia: A Review of Eleven Patients

      research Frontal fibrosing alopecia: a review of eleven patients

      8 citations , September 2011 in “European Journal of Dermatology”
      This study reports that most cases of frontal fibrosing alopecia did not show significant improvement with available treatments, and effective management remains unproven.
      Fibrosing Alopecia in a Pattern Distribution

      research Fibrosing Alopecia in a Pattern Distribution

      1 citations , July 2018 in “Elsevier eBooks”
      This review discusses the pathogenesis and clinical features of androgenetic alopecia, highlighting potential links to fibrosing alopecia and suggesting the need for combined therapeutic approaches; it reports no new clinical results.

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      community Reducing Fibrosis in Hair Loss: Topical Pirfenidone

       59 upvotes 5 months ago
      Topical pirfenidone is highlighted as an effective anti-inflammatory and anti-fibrotic treatment for hair loss, particularly in addressing perifollicular fibrosis, which may enhance the effectiveness of standard treatments like finasteride and minoxidil. The user also uses calcipotriol, MCT oil, ciclopirox shampoo, and benzoyl peroxide shampoo as part of their regimen.

      community Fibrosing alopecia in a pattern distribution

      in Research/Science  14 upvotes 2 years ago
      A user has been experiencing hair loss for 4 years, with treatments like minoxidil, finasteride, and various supplements proving ineffective. They were diagnosed with fibrosing alopecia in a pattern distribution, a condition that may require a combination of anti-inflammatory and hair growth treatments.

      community The Worst Hair Loss Condition You (MAY) have: LPP

       48 upvotes 2 years ago
      Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

      community Anti-oxidants that reverse hairloss?

       86 upvotes 5 years ago
      Resveratrol and fisetin, found in red wine and strawberries, may promote hair growth by affecting hair follicle cells. Users discuss various treatments, including natural remedies like saw palmetto and topical applications, with mixed opinions on their effectiveness compared to pharmaceuticals like finasteride.

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