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    Glossary Alpha-smooth muscle actin

    protein involved in smooth muscle contraction and wound healing

    Alpha-smooth muscle actin (α-SMA) is a protein that plays a crucial role in the contraction of smooth muscle cells, which are found in various tissues like blood vessels and the digestive tract. It is also a marker used by scientists to identify myofibroblasts, cells involved in wound healing and tissue repair. Elevated levels of α-SMA can indicate tissue remodeling or fibrosis, which is the thickening and scarring of connective tissue.

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    1. Formation of actin mesh structures and alpha-smooth muscle actin dynamics in fibroblasts contribute to dermal regeneration in mouse fetus PLoS ONE · 2025 · 1 citations
    2. Alpha Smooth Muscle Actin role in Androgenetic Alopecia Pathogenesis: Benha Journal of Applied Sciences · 2024
    3. Generation and Characterization of Multipotent Stem Cells from Established Dermal Cultures PLoS ONE · 2012 · 58 citations
    4. The repairing of full-thickness skin deficiency and its biological mechanism using decellularized human amniotic membrane as the wound dressing Materials Science and Engineering: C · 2017 · 47 citations
    5. A novel immune competent murine hypertrophic scar contracture model: A tool to elucidate disease mechanism and develop new therapies Wound Repair and Regeneration · 2014 · 35 citations
    6. Hyaluronic acid (HA)-based hydrogels for full-thickness wound repairing and skin regeneration Journal of Materials Science: Materials in Medicine · 2018 · 24 citations
    7. Effects of ginsenoside Rb1 on hypertrophic scar remodeling in rabbit model European journal of pharmacology · 2015 · 10 citations
    8. Wound healing mechanism in Mongolian gerbil skin Histochemistry and Cell Biology · 2018 · 6 citations
    9. Histological and immunohistochemical studies of excisional wounds in the rat with special reference to the involvement of the hair follicles in the wound healing process Durham e-Theses (Durham University) · 2000 · 4 citations
    10. 4-aminopyridine promotes accelerated skin wound healing via neurogenic-mediator expression Research Square (Research Square) · 2022
    11. A Mouse Model for Studying Stem Cell Effects on Regeneration of Hair Follicle Outer Root Sheaths Central European Journal of Biology · 2020
    12. Decellularized Wharton's jelly matrix as a three dimensional scaffold for wound healing and hair regeneration applications KU ScholarWorks (The University of Kansas) · 2016
    13. Human hair follicle dermal papilla cell, dermal sheath cell and interstitial dermal fibroblast characteristics. PubMed · 1996 · 36 citations
    14. Effects of Adipose-Derived Stem Cells and Platelet-Rich Plasma Exosomes on The Inductivity of Hair Dermal Papilla Cells. PubMed · 2021 · 5 citations
    15. Long-term Oral Administration of 5α-reductase Inhibitor Attenuates Erectile Function by Inhibiting Autophagy and Promoting Apoptosis of Smooth Muscle Cells in Corpus Cavernosum of Aged Rats Urology · 2013 · 34 citations
    16. Human hair follicle stem cell differentiation into contractile smooth muscle cells is induced by transforming growth factor-β1 and platelet-derived growth factor BB Molecular Medicine Reports · 2013 · 19 citations
    17. Combination of lyophilized adipose-derived stem cell concentrated conditioned medium and polysaccharide hydrogel in the inhibition of hypertrophic scarring Stem Cell Research & Therapy · 2021 · 45 citations
    18. Cellular response of keratinocytes to the entry and accumulation of nanoplastic particles Particle and Fibre Toxicology · 2024 · 26 citations
    19. Influence of conditioned media from glial cell cultures on contractility of uterine in rats of different ages Reproductive Endocrinology · 2022 · 1 citations
    20. Caffeine’s Mechanisms of Action and Its Cosmetic Use Skin Pharmacology and Physiology · 2012 · 153 citations
    21. MECHANISM OF ACTION OF AVICENNIA MARINA HEARTWOOD EXTRACT AND AVICEQUINONE C ON HUMAN DERMAL PAPILLA CELLS ISOLATED FROM ANDROGENIC ALOPECIA PATIENTS 2016
    22. 424 Grey-Scale Penile Ultrasound Findings in Young Men With Erectile Dysfunction (ED) Who Used Finasteride for Androgenic Alopecia The Journal of Sexual Medicine · 2016
    23. Identification of hepatic molecular mechanisms of action of alpha-tocopherol using global gene expression profile analysis in rats Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · 2004
    24. A multi-omic single-cell landscape of perinatal mouse skin maps lineage specification and reveals shared dynamics in human fetal skin Experimental & Molecular Medicine · 2026
    25. Changes in the Expression of Smooth Muscle Cell–Related Genes in Human Dermal Sheath Cup Cells Associated with the Treatment Outcome of Autologous Cell–Based Therapy for Male and Female Pattern Hair Loss International Journal of Molecular Sciences · 2022 · 2 citations
    26. Curly Hair Follicle is Sculpted by a Contracted Arrector Pili Muscle. A Hypothesis with Treatment Implications Indian Journal of Pharmaceutical Sciences · 2024
    27. Curly Hair Follicle is Sculpted by a Contracted Arrector Pili Muscle. A Hypothesis with Treatment Implications Indian Journal of Pharmaceutical Sciences · 2024
    28. Thyroid hormone action on skin Dermato-endocrinology · 2011 · 44 citations
    29. Thyroid hormone action on skin. PubMed · 2011 · 24 citations
    30. The prevention of benign prostatic hyperplasia (bph) Medical Hypotheses · 2016 · 12 citations