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GlossaryGlycogen Synthase Kinase 3

enzyme involved in regulating cell functions and signaling pathways

Glycogen Synthase Kinase 3 (GSK-3) is an enzyme that plays a crucial role in various cellular processes, including the regulation of glycogen synthesis, cell division, and cell survival. It is involved in multiple signaling pathways and can influence conditions like diabetes, Alzheimer's disease, and even hair growth by affecting cellular functions and gene expression.

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PBX Homeobox 1 Enhances Hair Follicle Mesenchymal Stem Cell Proliferation and Reprogramming Through Activation of the AKT/Glycogen Synthase Kinase Signaling Pathway and Suppression of Apoptosis

research PBX Homeobox 1 Enhances Hair Follicle Mesenchymal Stem Cell Proliferation and Reprogramming Through Activation of the AKT/Glycogen Synthase Kinase Signaling Pathway and Suppression of Apoptosis

26 citations , August 2019 in “Stem Cell Research & Therapy”

PBX1 helps hair stem cells grow and change by turning on certain cell signals and preventing cell death, which may be useful for hair regrowth treatments.

research Influencing Hair Regrowth With EGCG by Targeting Glycogen Synthase Kinase-3β Activity: A Molecular Dynamics Study

February 2025 in “Journal of Receptors and Signal Transduction”

EGCG may help regrow hair by inhibiting a specific enzyme.

Escin Activates Canonical Wnt/Beta-Catenin Signaling Pathway by Facilitating the Proteasomal Degradation of Glycogen Synthase Kinase-3 Beta in Cultured Human Dermal Papilla Cells

research Escin Activates Canonical Wnt/Beta-Catenin Signaling Pathway by Facilitating the Proteasomal Degradation of Glycogen Synthase Kinase-3 Beta in Cultured Human Dermal Papilla Cells

July 2023 in “Current Issues in Molecular Biology”

Escin may help treat hair loss by boosting a specific cell growth pathway.

research Discovery and Optimization of Novel Pyridines as Highly Potent and Selective Glycogen Synthase Kinase 3 Inhibitors

October 2019

New pyridine compounds effectively inhibit GSK3, a diabetes treatment target.

Hair Follicle Stem Cell Differentiation Is Inhibited Through Cross-Talk Between Wnt/β-Catenin and Androgen Signaling in Dermal Papilla Cells From Patients With Androgenetic Alopecia

research Hair Follicle Stem Cell Differentiation Is Inhibited Through Cross-Talk Between Wnt/β-Catenin and Androgen Signaling in Dermal Papilla Cells From Patients With Androgenetic Alopecia

95 citations , January 2012 in “British Journal of Dermatology”

Androgens block hair growth by disrupting cell signals; targeting GSK-3 may help treat hair loss.

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community Better Than Minoxidil? Topical Sodium Valproate

in Research/Science 51 upvotes 9 months ago

Topical sodium valproate may promote hair growth by inhibiting GSK3β, allowing beta-catenin to proliferate, but it has potential side effects and requires more research. The conversation also mentions skepticism about a product called Vdphlo1, which includes sodium valproate and other ingredients.

community AGA responded to steroid shots? Biopsy wrong? Please help!

in Female 2 upvotes 1 year ago

A woman with AGA is using spironolactone, dutasteride, finasteride, oral minoxidil, bicalutamide, and anti-androgenic birth control but still experiences worsening hair loss. Steroid shots temporarily stop her hair shedding, leading her to question her biopsy results.

community 57% increased chance of pattern hair loss independently associated with the consumption of sugary beverages in men (p<0.001) Pt 2

in Research/Science 479 upvotes 1 year ago

Sugary beverages increase the risk of pattern hair loss in men by 57%. Treatments discussed include Minoxidil, finasteride, and RU58841.

community 9 month update 1st slide 2020 at my worst vs today. 2nd slide 9 months ago vs today. 3rd, wet hair. 4th, hairline. 5th, damp hair. 6th crown view. 7th, brushed back. 8 & 9, hair in high Summer humidity. 10th, no lighting.

in Progress Pictures 342 upvotes 1 year ago

User shared 9-month hair regrowth progress using a Fin/Min spray from HIMS, with additional microneedling. Other users praised the results and discussed the effectiveness of topical treatments.

community Update about Hair Follicle Glucose Metabolism: New Clinical Data Collection with Ex-President Of American Board Of Hair Restoration Surgery.

in Research/Science 41 upvotes 1 year ago

David Barreto shared that a London-based research group is conducting a 12-month trial for a new nutraceutical treatment for pattern hair loss, designed with Dr. Carlos Puig. The trial aims to provide robust data, with results expected in 1-2 years, potentially representing a significant advancement since finasteride’s introduction in 1997.

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