Keratin 75 Is a Component of the LINC Complex and Has an Essential Role in Mediating the SOX2 Rapid Healing Response During Wound Repair

    September 2022 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    Andrew P. Sawaya, Akihiko Uchiyama, Emma Hope, Deepti Bajpai, Stephen Worrell, Michael A. Cross, Elia Beniash, Lisa M. Jenkins, Olivier Duverger, María I. Morasso
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    Studysummary This study found that enhanced wound healing in oral mucosa involves a SOX2-regulated transcriptional network which includes increased expression of keratin K75, and interaction of K75 with the LINC complex may play a crucial role in promoting rapid wound repair. Our plain-language summary of this paper — not a Tressless recommendation.
    The document presents a study on the role of Keratin 75 (K75) in wound healing, revealing that K75 is a direct target of the transcription factor SOX2, which is known for promoting rapid wound repair in the oral epithelium. The study utilized a tamoxifen-inducible mouse model to show that SOX2 upregulates K75 expression in the interfollicular epidermis. Additionally, K75 was found to be a part of the linker of nucleoskeleton and cytoskeleton (LINC) complex, which is responsible for transmitting mechanical signals that influence gene expression. The interaction between K75 and SUN2, a LINC complex component, was shown to be crucial for the SOX2-mediated rapid healing response. Knockdown experiments of K75 or SUN2 disrupted keratinocyte migration and negated the healing effects of SOX2 overexpression, underscoring the importance of K75 in wound healing beyond its structural role in hair, teeth, and feathers.
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