The Role of Box A of HMGB1 in Enhancing Stem Cell Properties of Human Mesenchymal Cells: A Novel Approach for the Pursuit of Anti-Aging Therapy

The study investigated the role of Box A of HMGB1 in enhancing stem cell properties in human dermal papilla cells and primary human white pre-adipocytes. By using Box A-overexpressing plasmids, researchers observed a significant increase in the proliferative rate and expression of stemness markers OCT4, NANOG, and SOX2 in both cell types. The findings suggest that Box A can enhance stemness, potentially improving stem cell function in aging and disease, with implications for regenerative medicine.