Scoparone Induces Expression of Pluripotency Transcription Factors SOX2 and NANOG in Dermal Papilla Cells

    January 2021 in “ in Vivo ”
    Nattha Suwanprakorn, Pithi Chanvorachote, Thitiporn Tongyen, Boonchoo Sritularak, Pichit Suvanprakorn
    Image of study
    TLDR Scoparone may help stimulate hair growth by increasing stem cell-related proteins in skin cells.
    In 2021, a study found that scoparone, a natural compound, significantly increased the expression of pluripotency-related transcription factors SOX2 and NANOG in dermal papilla cells (DPCs), which are crucial for hair follicle development. The compound exerted its effects through the up-regulation of Akt-dependent inhibition of GSK3β, leading to increased cellular levels of β-catenin, a protein that regulates stem cell functions. This suggests that scoparone could potentially be used to stimulate hair growth by maintaining the stemness of DPCs.
    Discuss this study in the Community →