Inhibition of the Hippo Pathway by Verteporfin Reduces the Proliferation and Stemness of Rat Hair Follicle Neural Crest Stem Cells Under Hypoxia

February 2025 in “ FASEB BioAdvances ”

Weihai Liu, Suhua Chen, Xin Chen, Lixiang Xue, Yan Wang, Jun Yang

Hippo pathway verteporfin hair follicle neural crest stem cells hypoxia HIF2α SOX10 OCT4 NANOG SOX2 KLF4 Visudyne

Studysummary In this study, hypoxic conditions were found to enhance stemness in hair follicle neural crest stem cells, while inhibiting the Hippo pathway significantly decreased their proliferation.

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