Therapeutic Potential of Hair Follicle-Derived Stem Cell Intranasal Transplantation in a Rat Model of Ischemic Stroke

    July 2022 in “ BMC neuroscience ”
    Seyedeh Maryam Mousavi, Bijan Akbarpour, Saeideh Karimi‐Haghighi, Sareh Pandamooz, Ivaldo Jesus Almeida Belém-Filho, Marianella Masís-Calvo, Haniye Salimi, Ramin Lashanizadegan, Alireza Pouramini, Maryam Owjfard, Etrat Hooshmandi, Mahnaz Bayat, Seyedeh Shaghayegh Zafarmand, Mehdi Dianatpour, Mohammad Saied Salehi, Afshin Borhani‐Haghighi
    Image of study
    TLDR Transplanted hair follicle stem cells improved brain function and reduced damage after a stroke in rats.
    The study investigated the therapeutic potential of hair follicle-derived stem cells (HFSCs) in treating ischemic stroke in rats. The researchers used 72 male rats, divided into control, placebo, and treatment groups. The HFSCs were obtained from adult rat hair follicles and administered intranasally either immediately after inducing stroke or 24 hours later. The results showed that rats treated with HFSCs had improved neurological performance and a reduced area of dead tissue due to lack of blood supply. The study also found changes in the expression of several trophic factors and a mature neuron marker in the brain following stroke and stem cell therapy. These findings suggest that HFSCs could potentially be a safe and effective treatment for ischemic stroke.
    Discuss this study in the Community →

    Research cited in this study

    2 / 2 results

    Related Community Posts Join

    6 / 1000+ results

      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  42 upvotes 4 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

      community Anyone Try Microneedling with Exosomes/AAPE?

      in Microneedling  2 upvotes 2 years ago
      User asks where to purchase exosomes/AAPE for microneedling hair loss treatment. Links to research on hair regeneration therapy, stem cell therapy, exosome therapy, and dermal exosomes provided.

      community How Does Exosome Therapy Work for Hair Loss?

      in Research/Science  5 upvotes 1 year ago
      Exosome hair therapy involves injecting stem cell-derived exosomes into the scalp to boost hair follicle regeneration and repair. Exosomes, which are not stem cells but products of them, contain bioactive chemicals and specific growth factors that promote new blood vessel formation, increase cell proliferation, reduce inflammation, and improve tissue repair, all crucial for hair health.

      community New potential hair loss treatment (news release)

      in Treatment  186 upvotes 4 years ago
      New potential hair loss treatment uses molecules from hairy moles to stimulate follicle growth. Topical solution requires less frequent application, like Botox injections a few times per year.

    Similar Research

    5 / 1000+ results