TLDR Transplanted hair follicle stem cells improved brain function and reduced damage after a stroke in rats.
The study investigated the therapeutic potential of hair follicle-derived stem cells (HFSCs) in treating ischemic stroke in rats. The researchers used 72 male rats, divided into control, placebo, and treatment groups. The HFSCs were obtained from adult rat hair follicles and administered intranasally either immediately after inducing stroke or 24 hours later. The results showed that rats treated with HFSCs had improved neurological performance and a reduced area of dead tissue due to lack of blood supply. The study also found changes in the expression of several trophic factors and a mature neuron marker in the brain following stroke and stem cell therapy. These findings suggest that HFSCs could potentially be a safe and effective treatment for ischemic stroke.
44 citations,
January 2015 in “Development” Human Schwann cells can be quickly made from hair follicle stem cells for nerve repair.
13 citations,
September 2014 in “Birth defects research” Human epidermal neural crest stem cells could be used for therapies, drug discovery, and disease modeling.
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88 citations,
January 2019 in “Journal of Tissue Engineering and Regenerative Medicine” Conditioned media from mesenchymal stem cell cultures could be a more effective alternative for regenerative therapies, but more research is needed.
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1160 citations,
November 2018 in “Physiological Reviews” The document concludes that better targeted treatments are needed for wound healing, and single-cell technologies may improve cell-based therapies.
Valproic acid and rapamycin protect hair follicle stem cells from damage by activating a protective pathway.
1 citations,
December 2022 in “Animals” Blocking miR-27a increases sheep hair follicle stem cell growth and decreases cell death, which could help improve wool quality and treat hair loss.
113 citations,
November 2017 in “Scientific Reports” Tiny particles from stem cells help activate hair growth cells and encourage hair growth in mice without being toxic.
