Hair Follicle Stem Cell-Derived Secretome Protects Astrocytes in an In Vitro Ischemia/Reperfusion Model

March 2025 in “ Anatomy & Cell Biology ”

Fatemeh Jameie, Mehdi Dianatpour, Mahintaj Dara, Zahra Jamali, Nasrin Ghorbani, Gökhan Ünal, Mohammad Saied Salehi, Sareh Pandamooz

hair follicle stem cell HFSC secretome astrocytes ischemia reperfusion oxygen-glucose deprivation pro-inflammatory cytokine neurotrophic factor apoptosis

TLDR Hair follicle stem cell secretions may help protect brain cells and improve stroke recovery.

This study explores the protective effects of hair follicle stem cell (HFSC)-derived secretome on astrocytes in an in vitro ischemia/reperfusion model. The HFSC-secretome treatment significantly reduces cell death and apoptosis, decreases pro-inflammatory cytokines (IL-6, IL-1β, TNF-α), and increases neurotrophic factors (BDNF, VEGF) in astrocytes. These results suggest that HFSC-derived secretome has neuroprotective, anti-inflammatory, and anti-apoptotic effects, potentially aiding brain repair and improving stroke recovery outcomes. The study emphasizes the need for in vivo research to confirm these findings and assess clinical applications.

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Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 11 months ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community PP405: The Ultimate Hair Loss Drug for Complete Hair Growth

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PP405 is a new hair loss treatment in phase 2 trials that may promote hair growth by increasing lactate production and activating hair follicle stem cells. It could potentially replace hormone-disrupting treatments like Minoxidil and finasteride.

community GT20029 and PP405 the new fin and min that we been waiting for ?

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PP405 and GT20029 are new hair loss treatments with different mechanisms from traditional options like Minoxidil and Finasteride. PP405 targets hair follicle stem cells to reactivate growth, while GT20029 works as an androgen receptor deleter, both requiring ongoing use for effectiveness.

community Eirion Therapeutics Announces Potential Breakthrough Treatment for Hair Loss Based on First-in-Man Clinical Trial Results

in Update 415 upvotes 8 months ago

ET-02, a new hair loss treatment, shows promising results with a 6-fold increase in hair count, potentially outperforming minoxidil by activating stem cells in hair follicles. Further trials are ongoing to confirm its efficacy and safety, with potential market release in the future.

community PP405 Drug in Action: Picture From Official Company Website

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community redensyl - follicle stem cell activator any experiences?

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A Swiss product called Redensyl, which is supposed to target hair follicle stem cells and has recently been marketed in Europe. The post inquires if anyone has had any experience with the product.

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