Hair Follicle Stem Cell-Derived Secretome Protects Astrocytes in an In Vitro Ischemia/Reperfusion Model

    March 2025 in “ Anatomy & Cell Biology
    Fatemeh Jameie, Mehdi Dianatpour, Mahintaj Dara, Zahra Jamali, Nasrin Ghorbani, Gökhan Ünal, Mohammad Saied Salehi, Sareh Pandamooz
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    TLDR Hair follicle stem cell secretions may help protect brain cells and improve stroke recovery.
    This study explores the protective effects of hair follicle stem cell (HFSC)-derived secretome on astrocytes in an in vitro ischemia/reperfusion model. The HFSC-secretome treatment significantly reduces cell death and apoptosis, decreases pro-inflammatory cytokines (IL-6, IL-1β, TNF-α), and increases neurotrophic factors (BDNF, VEGF) in astrocytes. These results suggest that HFSC-derived secretome has neuroprotective, anti-inflammatory, and anti-apoptotic effects, potentially aiding brain repair and improving stroke recovery outcomes. The study emphasizes the need for in vivo research to confirm these findings and assess clinical applications.
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