5 citations
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November 2022 in “Molecular Neurobiology” Melatonin may protect inner ear cells from damage by reducing cell death and oxidative stress, potentially treating sudden hearing loss.
In this study, preconditioning hair follicle-derived stem cells with valproic acid and/or rapamycin was shown to protect against damage caused by oxygen glucose and serum deprivation, potentially enhancing stem cell therapy efficacy for ischemic stroke by improving cell adaptation to oxidative stress.
83 citations
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November 2006 in “European Journal of Neuroscience” This study found that progesterone protects rat Purkinje cells during oxygen-glucose deprivation by activating GABA A receptors through its metabolite, allopregnanolone.
16 citations
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November 2011 in “Neuroscience Letters” This study reported that progesterone reduces cell death in hippocampal cultures following oxygen–glucose deprivation mainly through its conversion to allopregnanolone and the involvement of GABAA receptors.
December 2025 in “Scientific Reports” This study found that preconditioning human hair follicle-derived stem cells with valproic acid enhanced their survival and migration in ischemic-like conditions by activating autophagy and inhibiting the AKT/mTOR pathway, suggesting this approach could improve stem cell therapies for ischemic stroke.
