The study investigates the therapeutic effects of hepatocyte growth factor (HGF)-modified hair follicle stem cells (HFSCs) on cerebral ischemia/reperfusion injury in rats. HFSCs were transplanted into a rat model, resulting in significant inhibition of microglia activation, improved blood-brain barrier integrity, and reduced brain edema. Additionally, HFSC transplantation increased neuron survival and microvessel density, enhancing neurological outcomes. The combination of HFSCs and HGF further improved these therapeutic benefits, suggesting that HGF-modified HFSCs can effectively reduce ischemic injury and promote neurological recovery by mitigating inflammation, protecting the blood-brain barrier, and encouraging angiogenesis.
11 citations
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September 2019 in “The journal of investigative dermatology/Journal of investigative dermatology” A specific group of skin stem cells was found to help maintain hair follicle cells.
10 citations
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January 2014 in “BioMed research international” Rat whisker cells can help turn other cells into nerve cells and might be used to treat brain injuries or diseases.
419 citations
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March 2005 in “Proceedings of the National Academy of Sciences” Hair-follicle stem cells can become neurons.
March 2025 in “Anatomy & Cell Biology” Hair follicle stem cell secretions may help protect brain cells and improve stroke recovery.
27 citations
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January 2020 in “Experimental Dermatology” Immune cells affect hair growth and could lead to new hair loss treatments.
245 citations
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January 2018 in “Bone Research” TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.
April 2024 in “The Journal of experimental medicine/The journal of experimental medicine” Treg cells help repair and regenerate tissues by interacting with local cells.
2 citations
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January 2023 in “International journal of biological sciences” Gray hair can potentially be reversed, leading to new treatments.
