Hepatocyte Growth Factor-Modified Hair Follicle Stem Cells Ameliorate Cerebral Ischemia/Reperfusion Injury in Rats

    February 2023 in “ Stem Cell Research & Therapy ”
    Hao Tang, Xuemei Zhang, Xiaojun Hao … Jin Fu
    Studysummary This study found that injecting hepatocyte growth factor-enhanced hair follicle stem cells into a rat model of ischemic stroke improved recovery by reducing inflammation, protecting the blood-brain barrier, and promoting angiogenesis.
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    Research cited in this study 4

    1. Transplanted Hair Follicle Stem Cells Migrate to the Penumbra and Express Neural Markers in a Rat Model of Cerebral Ischemia/Reperfusion Stem Cell Research & Therapy · 2020
    2. CD49fhigh Defines a Distinct Skin Mesenchymal Stem Cell Population Capable of Hair Follicle Epithelial Cell Maintenance ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2019
    3. Multipotent Neural Crest Stem Cell-Like Cells from Rat Vibrissa Dermal Papilla Induce Neuronal Differentiation of PC12 Cells BioMed research international · 2014
    4. Multipotent Nestin-Positive, Keratin-Negative Hair-Follicle Bulge Stem Cells Can Form Neurons Proceedings of the National Academy of Sciences · 2005